Reduction of risk factors following lifestyle modification programme in subjects with type 2 (non-insutin dependent) diabetes mellitus

被引:31
作者
Krook, A
Holm, I
Pettersson, S
Wallberg-Henriksson, H
机构
[1] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden
[2] Lillsved Gymnastikfolkhogskola, Varmdo, Sweden
[3] Nacka Hosp, Nacka, Sweden
关键词
blood pressure; exercise; haemoglobin A(1c) lifestyle modification programme; type; 2; diabetes;
D O I
10.1046/j.1475-097X.2003.00463.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Exercise and improved diet is known to be beneficial in the management of type 2 (non-insulin dependent) diabetes mellitus. In practice, however, it is difficult for patients to implement these changes unaided. We hypothesized that a lifestyle modification programme involving residential visits would result in beneficial effects on glycaemic control and lipid profile. Three hundred and four individuals with type 2 diabetes participated in a lifestyle modification programme, involving three residential visits (2 weeks, 1 week and one 3-day visit) spaced over 31 weeks. The subjects were all referred for treatment following repeated failure to achieve metabolic control in primary care settings. Participants received information and practical guidance regarding exercise training, nutrition, as well as stress management and psychological counselling. Clinical parameters were determined at each visit. After completion of the programme, subjects showed significant improvements in glycaemic control (P<0(.)0001). Oxygen uptake was significantly improved (P<0(.)0001) and blood pressure (P<0(.)0001), body mass index (P<0.0001) and serum cholesterol (P<0(.)001) was significantly reduced, while HDL cholesterol (P<0(.)05) was significantly increased. There were no changes in LDL cholesterol values. Subjects also reported increased well-being and reduced stress. In conclusion, a 31-week lifestyle modification programme results in marked improvements in glycaemic control, blood pressure and well-being in subjects with type 2 diabetes. Thus, this type of lifestyle modification programme is a powerful treatment option to reduce risk factors associated with diabetes and diabetic complications, even in patients who have not responded to conventional diabetic therapy.
引用
收藏
页码:21 / 30
页数:10
相关论文
共 36 条
  • [1] Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
    Adler, AI
    Stratton, IM
    Neil, HAW
    Yudkin, JS
    Matthews, DR
    Cull, CA
    Wright, AD
    Turner, RC
    Holman, RR
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2000, 321 (7258): : 412 - 419
  • [2] Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO
  • [3] 2-S
  • [4] RISK-FACTORS AND REPORTED SICK LEAVE AMONG EMPLOYEES OF SAAB-SCANIA, LINKOPING, SWEDEN, BETWEEN THE AGES OF 50 AND 59
    ANDERSSON, G
    MALMGREN, S
    [J]. SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE, 1986, 14 (01): : 25 - 30
  • [5] [Anonymous], ACTA PHYSIOLOGICA S
  • [6] Bergstrom K, 1999, EDTNA ERCA J, V25, P42
  • [7] IMPAIRED GLUCOSE-TOLERANCE AND NIDDM - DOES A LIFE-STYLE INTERVENTION PROGRAM HAVE AN EFFECT
    BOURN, DM
    MANN, JI
    MCSKIMMING, BJ
    WALDRON, MA
    WISHART, JD
    [J]. DIABETES CARE, 1994, 17 (11) : 1311 - 1319
  • [8] Castelli W P, 1992, Ann Epidemiol, V2, P23, DOI 10.1016/1047-2797(92)90033-M
  • [9] Prevention of Type II diabetes in subjects with impaired glucose tolerance:: the Diabetes Prevention Study (DPS) in Finland -: Study design and 1-year interim report on the feasibility of the lifestyle intervention programme
    Eriksson, J
    Lindström, J
    Valle, T
    Aunola, S
    Hämäläinen, H
    Ilanne-Parikka, P
    Keinänen-Kiukaanniemi, S
    Laakso, M
    Lauhkonen, M
    Lehto, P
    Lehtonen, A
    Louheranta, A
    Mannelin, M
    Martikkala, V
    Rastas, M
    Sundvall, J
    Turpeinen, A
    Viljanen, T
    Uusitupa, M
    Tuomilehto, J
    [J]. DIABETOLOGIA, 1999, 42 (07) : 793 - 801
  • [10] PREVENTION OF TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS BY DIET AND PHYSICAL EXERCISE - THE 6-YEAR MALMO FEASIBILITY STUDY
    ERIKSSON, KF
    LINDGARDE, F
    [J]. DIABETOLOGIA, 1991, 34 (12) : 891 - 898