Batch Preparation and Characterization of Electrospun Porous Polylactic Acid-Based Nanofiber Membranes for Antibacterial Wound Dressing

被引：124

作者：

Yin, Jing ^{[1
]}

Xu, Lan ^{[1
]}

Ahmed, Adnan ^{[1
]}

机构：

[1] Soochow Univ, Coll Text & Clothing Engn, Natl Engn Lab Modern Silk, Suzhou, Peoples R China

来源：

ADVANCED FIBER MATERIALS | 2022年 / 4卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Batch preparation; Polylactic acid; chitosan; aloin; Nanofiber membranes; Spherical section free surface electrospinning; Antibacterial wound dressings; FABRICATION; SCAFFOLDS; SURFACE; FIBERS; BLEND; CELLS; ALOIN;

D O I：

10.1007/s42765-022-00141-y

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A good wound dressing needs to promote wound healing and tissue repair when the skin is injured. In this study, a self-made spherical section free surface electrospinning device was used to produce large quantities of electrospun porous polylactic acid (PLA)/chitosan (CS)/aloin nanofiber membranes (NFMs) for antibacterial wound dressing. The porous structures of PLA-based nanofibers were controlled by adjusting the weight ratios of mixed solvent and solute. The results showed that high-quality porous PLA/CS/aloin (PCA) NFMs were obtained when the weight ratios of chloroform/N, N-dimethylformamide and PLA: CS were 90/10 and 7:1, respectively. The porous PCA NFMs exhibited high porosity, acceptable mechanical properties, moderate hydrophobicity, good swelling property, and high water vapor transmission rate. Moreover, they also showed excellent blood coagulative, antibacterial, biocompatible properties, which had the potential to be used in the application of antibacterial wound dressings.

引用

页码：832 / 844

页数：13

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