Bis(thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease

被引：69

作者：

Fodero-Tavoletti, Michelle T. ^{[2
,3
,4
]}

Villemagne, Victor L. ^{[1
,2
,4
]}

Paterson, Brett M. ^{[3
,5
]}

White, Anthony R. ^{[2
,4
,6
]}

Li, Qiao-Xin ^{[2
,4
]}

Camakaris, James ^{[7
]}

O'Keefe, Graeme J. ^{[1
]}

Cappai, Roberto ^{[2
,3
]}

Barnham, Kevin J. ^{[2
,3
,4
]}

Donnelly, Paul S. ^{[3
,5
]}

机构：

[1] Austin Hlth, Ctr PET, Dept Nucl Med, Heidelberg, Vic 3010, Australia

[2] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia

[3] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic 3010, Australia

[4] Mental Hlth Res Inst, Melbourne, Vic, Australia

[5] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia

[6] Univ Melbourne, Ctr Neurosci, Melbourne, Vic 3010, Australia

[7] Univ Melbourne, Dept Genet, Melbourne, Vic 3010, Australia

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 20卷 / 01期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

Alzheimer's disease; copper homeostasis; copper radiopharmaceuticals; diagnostic imaging; positron emission tomography (PET); AMYLOID-BETA-PEPTIDE; A-BETA; IN-VITRO; COPPER; BINDING; MECHANISMS; OLIGOMERS; BRAIN; ZINC; MICE;

D O I：

10.3233/JAD-2010-1359

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target amyloid-beta plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.

引用

页码：49 / 55

页数：7

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