Ancistrolikokine D, a 5.8′-coupled naphthylisoquinoline alkaloid and related natural products from Ancistrocladus likoko

被引：34

作者：

Bringmann, G ^{[1
]}

Saeb, W

Rückert, M

Mies, J

Michel, M

Mudogo, V

Brun, R

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Univ Kinshasa, Fac Sci, Kinshasa, DEM REP CONGO

[3] Swiss Trop Inst, CH-4002 Basel, Switzerland

来源：

PHYTOCHEMISTRY | 2003年 / 62卷 / 04期

关键词：

Ancistroclacdus likoko; Ancistrocladaceae; structural elucidation; naphthylisoquinoline alkaloids; Ancistrolikokine D; ancistroealaine A; ancistronaphthoic acid B; isoshinanolone; antiprotozoal activity;

D O I：

10.1016/S0031-9422(02)00570-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new naphthylisoquinoline alkaloid, ancistrolikokine D, and the likewise 5,8'-coupled alkaloid ancistroealaine A, as well as two further, biosynthetically related, but nitrogen-free natural products, ancistronaphthoic acid B and cis-isoshinanolone, have been isolated from Ancistrocladus likoko J. LEONARD (Ancistrocladaceae). The 5,8'-coupling of the new alkaloids and of the alkaloids isolated earlier hints at a close phylogenetic relationship of A. likoko to other Central African Ancistrocladus species. The compounds show moderate activities against Leishmania donovani, Trypanosoma cruzi., and Trypanosoma brucei rhodesiense. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：631 / 636

页数：6

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