Annexin A1 regulates TGF-β signaling and promotes metastasis formation of basal-like breast cancer cells

被引：175

作者：

de Graauw, Marjo ^{[1
]}

van Miltenburg, Martine H. ^{[1
]}

Schmidt, Marjanka K. ^{[2
]}

Pont, Chantal ^{[1
]}

Lalai, Reshma ^{[1
]}

Kartopawiro, Joelle ^{[1
]}

Pardali, Evangelia ^{[3
,4
]}

Le Devedec, Sylvia E. ^{[1
]}

Smit, Vincent T. ^{[5
]}

van der Wal, Annemieke ^{[5
]}

Van't Veer, Laura J. ^{[2
]}

Cleton-Jansen, Anne-Marie ^{[5
]}

ten Dijke, Peter ^{[3
,4
]}

van de Water, Bob ^{[1
]}

机构：

[1] Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Toxicol, NL-2300 RA Leiden, Netherlands

[2] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Pathol, NL-1066 CX Amsterdam, Netherlands

[3] Leiden Univ, Med Ctr, Dept Mol Cell Biol, NL-2300 RA Leiden, Netherlands

[4] Leiden Univ, Med Ctr, Ctr Biomed Genet, NL-2300 RA Leiden, Netherlands

[5] Leiden Univ, Med Ctr, Dept Pathol, NL-2300 RC Leiden, Netherlands

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 14期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; MAMMARY ADENOCARCINOMA; DOWN-REGULATION; EARLY ENDOSOMES; EXPRESSION; GENE; LINES; SUBTYPES; DIFFERENTIATION; INTERNALIZATION;

D O I：

10.1073/pnas.0913360107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Annexin A1 (AnxA1) is a candidate regulator of the epithelial-to mesenchymal (EMT)-like phenotypic switch, a pivotal event in breast cancer progression. We show here that AnxA1 expression is associated with ahighly invasivebasal- likebreast cancer subtypeboth in apanel of human breast cancer cell lines as in breast cancer patients and that AnxA1 is functionally related to breast cancer progression. AnxA1 knockdownininvasivebasal- likebreast cancer cells reduced the number of spontaneous lung metastasis, whereas additional expression of AnxA1 enhanced metastatic spread. AnxA1 promotes metastasis formation by enhancingTGF beta/Smad signalingandactin reorganization, which facilitates an EMT-like switch, thereby allowing ef. cient cell migration and invasion of metastatic breast cancer cells.

引用

页码：6340 / 6345

页数：6

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