RNA modifications modulate gene expression during development

被引：920

作者：

Frye, Michaela ^{[1
,2
]}

Harada, Bryan T. ^{[3
,4
,5
]}

Behm, Mikaela ^{[1
]}

He, Chuan ^{[3
,4
,5
,6
]}

机构：

[1] Univ Cambridge, Dept Genet, Downing St, Cambridge CB2 3EH, England

[2] German Canc Ctr DKFZ, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[3] Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA

[4] Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA

[5] Univ Chicago, Howard Hughes Med Inst, 5841 S Maryland Ave, Chicago, IL 60637 USA

[6] Univ Chicago, Dept Biochem & Mol Biol, 920 E 58Th St, Chicago, IL 60637 USA

来源：

SCIENCE | 2018年 / 361卷 / 6409期

基金：

欧洲研究理事会; 英国医学研究理事会; 美国国家卫生研究院;

关键词：

HEMATOPOIETIC STEM; SELF-RENEWAL; M(6)A; TRANSLATION; METHYLATION; PROTEIN; DIFFERENTIATION; FRAGMENTS; REVEALS; CELLS;

D O I：

10.1126/science.aau1646

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA ( mRNA) modifications regulate various aspects of mRNA metabolism. For example, N-6-methyladenosine (m(6)A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition. Similarly, some modifications in transfer RNAs are essential for RNA structure and function. Others are deposited in response to external cues and adapt global protein synthesis and gene-specific translation accordingly and thereby facilitate proper development.

引用

页码：1346 / 1349

页数：4

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