Reduced T cell immunity in unmedicated, comorbidity-free obsessive-compulsive disorder: An immunophenotyping study

被引:6
作者
Subbanna, Manjula [1 ,3 ]
Shivakumar, Venkataram [2 ,3 ]
Jose, Dania [3 ]
Venkataswamy, Manjunath [4 ]
Debnath, Monojit [1 ]
Ravi, Vasanthapuram [4 ]
Reddy, Y. C. Janardhan [5 ]
Venkatasubramanian, Ganesan [3 ,5 ]
Narayanaswamy, Janardhanan C. [3 ,5 ]
机构
[1] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Human Genet, Bengaluru 560029, India
[2] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Integrat Med, Bengaluru 560029, India
[3] Natl Inst Mental Hlth & Neurosci NIMHANS, Translat Psychiat Lab, Bengaluru 560029, India
[4] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Neurovirol, Bengaluru 560029, India
[5] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Psychiat, OCD Clin, Bengaluru 560029, India
基金
英国惠康基金;
关键词
Obsessive-compulsive disorder; T cells; T regulatory cells; Inflammation; Autoimmunity; Immunophenotyping; SCALE; TOLERANCE;
D O I
10.1016/j.jpsychires.2021.03.035
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Immune system aberrations have been postulated to play a role in the pathophysiology of Obsessivecompulsive disorder (OCD). This study was aimed to examine the profile of immune cell subsets in peripheral blood of un-medicated OCD patients. Method: Thirteen drug-na?ve/free OCD patients and twenty-six age & sex matched healthy controls were recruited. Immunophenotyping was carried out by staining the whole blood specimens with fluorescent monoclonal antibodies against the cell surface markers such as CD45, CD3, CD16, CD56, CD8, CD4, CD28, CD25 and CD127, followed by data acquisition on BD FACSVerseTM flow cytometer. The proportions of CD4 and CD8 T cells; T regulatory (Tregs), Natural Killer (NK) cells and NK-T cells were compared between patients with OCD and healthy control subjects. Results: Significantly reduced percentage of T regulatory (Treg) cells was observed in individuals with OCD compared to healthy control subjects [1.0 ? 0.7 vs. 1.9 ? 1.4; p = 0.03, r = 0.33]. Conclusion: Treg cells play a crucial role in regulating the immune response, especially by suppressing the functional activities of T cells. In this study, decreased population of Treg cells essentially indicates a dysregulated T cell and/or T cell mediated immune activation in drug-na?ve OCD patients. This preliminary observation might form the basis of further studies examining the immuno-inflammatory/autoimmune origin of OCD.
引用
收藏
页码:521 / 524
页数:4
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