Segmental duplications in subtelomeric regions of human chromosome 13

被引：1

作者：

Kupriyanova, NS ^{[1
]}

Shibalev, DV

Voronov, AS

Muravenk, OV

Zelenin, AV

Ryskov, AP

机构：

[1] Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia

[2] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

来源：

MOLECULAR BIOLOGY | 2003年 / 37卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

human chromosome 13; segmental duplication; subtelomeric and pericentric nucleotide sequences; ribosomal DNA; genome evolution;

D O I：

10.1023/A:1023385319390

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Owing to a great progress in studying the human genome, its euchromatic portion is almost completely sequenced; the complete sequence is still unknown only for pericentric and telomeric regions and short arms of acrocentric chromosomes. Extended satellite blocks and segmental duplications located in these regions substantially hinder the joining of the sequenced fragments and construction of the full-length genome map. The sequence was established for a 1.5-kb human chromosome 13 subtelomeric region, which is about 10 kb away from the rDNA cluster, and deposited in GenBank under accession no. AF478540. The region showed 83-84% homology to the pericentric region of human chromosome 19, and contained short fragments homologous to the pericentric region of human chromosome 13. The results may contribute to the current revision of genome evolution concepts in view of numerous segmental duplications revealed.

引用

页码：194 / 199

页数：6

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