Role of ubiquitination in meiotic recombination repair

被引：6

作者：

Li, Cui ^{[1
]}

Wei, Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2010年 / 53卷 / 04期

基金：

中国国家自然科学基金;

关键词：

ubiquitin; meiosis; homologous recombination; DNA double-strand breaks; DOUBLE-STRAND BREAKS; SACCHAROMYCES-CEREVISIAE; POLYUBIQUITIN CHAINS; HISTONE H2B; RING FINGER; ATM ACTIVATION; TARGETS BRCA1; DNA-REPAIR; PROTEIN; COMPLEX;

D O I：

10.1007/s11427-010-0052-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Programmed and unprogrammed double-strand breaks (DSBs) often arise from such physiological requirements as meiotic recombination, and exogenous insults, such as ionizing radiation (IR). Due to deleterious impacts on genome stability, DSBs must be appropriately processed and repaired in a regulatory manner. Recent investigations have indicated that ubiquitination is a critical factor in DNA damage response and meiotic recombination repair. This review summarizes the effects of proteins and complexes associated with ubiquitination with regard to homologous recombination (HR)-dependent DSB repair.

引用

页码：447 / 454

页数：8

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