Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey

被引：35

作者：

Wang, Guan-Ying ^{[1
]}

Zhang, Sa-Li ^{[1
]}

Wang, Xiu-Ru ^{[2
]}

Feng, Min ^{[1
]}

Li, Chun ^{[1
]}

An, Yuan ^{[1
]}

Li, Xiao-Feng ^{[3
]}

Wang, Li-Zhi ^{[3
]}

Wang, Cai-Hong ^{[3
]}

Wang, Yong-Fu ^{[4
]}

Yang, Rong ^{[4
]}

Yan, Hui-Ming ^{[4
]}

Wang, Guo-Chun ^{[5
]}

Lu, Xin ^{[5
]}

Liu, Xia ^{[5
]}

Zhu, Ping ^{[6
]}

Chen, Li-Na ^{[6
]}

Jin, Hong-Tao ^{[7
]}

Liu, Jin-Ting ^{[7
]}

Guo, Hui-Fang ^{[7
]}

Chen, Hai-Ying ^{[8
]}

Xie, Jian-Li ^{[8
]}

Wei, Ping ^{[8
]}

Wang, Jun-Xiang ^{[8
]}

Liu, Xiang-Yuan ^{[9
]}

Sun, Lin ^{[9
]}

Cui, Liu-Fu ^{[10
]}

Shu, Rong ^{[10
]}

Liu, Bai-Lu ^{[10
]}

Yu, Ping ^{[10
]}

Zhang, Zhuo-Li ^{[11
]}

Li, Guang-Tao ^{[11
]}

Li, Zhen-Bin ^{[12
]}

Yang, Jing ^{[12
]}

Li, Jun-Fang ^{[13
]}

Jia, Bin ^{[13
]}

Zhang, Feng-Xiao ^{[14
]}

Tao, Jie-Mei ^{[14
]}

Lin, Jin-Ying ^{[15
]}

Wei, Mei-Qiu ^{[15
]}

Liu, Xiao-Min ^{[16
]}

Ke, Dan ^{[16
]}

Hu, Shao-Xian ^{[17
]}

Ye, Cong ^{[17
]}

Han, Shu-Ling ^{[2
]}

Yang, Xiu-Yan ^{[18
]}

Li, Hao ^{[18
]}

Huang, Ci-Bo ^{[19
]}

Gao, Ming ^{[19
]}

Lai, Bei ^{[19
]}

机构：

[1] Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China

[2] Peking Univ, Dept Rheumatol & Immunol, Shougang Hosp, Beijing 100044, Peoples R China

[3] Shanxi Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, Taiyuan, Shanxi, Peoples R China

[4] Baotou Med Coll, Dept Rheumatol & Immunol, Affiliated Hosp 1, Baotou, Inner Mongolia, Peoples R China

[5] China Japan Friendship Hosp, Dept Rheumatol, Beijing, Peoples R China

[6] Fourth Mil Med Univ, Dept Rheumatol & Immunol, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China

[7] Hebei Med Univ, Dept Rheumatol & Immunol, Hosp 2, Shijiazhuang, Hebei, Peoples R China

[8] Hebei Med Univ, Dept Rheumatol & Immunol, Hosp 3, Shijiazhuang, Hebei, Peoples R China

[9] Peking Univ, Dept Rheumatol & Immunol, Hosp 3, Beijing 100044, Peoples R China

[10] North China Coal Med Univ, Dept Rheumatol & Immunol, Affiliated Kailuan Hosp, Tangshan, Hebei, Peoples R China

[11] Peking Univ, Dept Rheumatol & Immunol, Hosp 1, Beijing 100044, Peoples R China

[12] Bethune Int Peace Hosp, Dept Rheumatol & Immunol, Shijiazhuang, Hebei, Peoples R China

[13] Cent Hosp Handan City, Dept Rheumatol & Immunol, Handan, Hebei, Peoples R China

[14] Hebei Peoples Hosp, Dept Rheumatol & Immunol, Shijiazhuang, Hebei, Peoples R China

[15] Peoples Hosp Guangxi, Dept Rheumatol & Immunol, Nanning, Guangxi, Peoples R China

[16] China Med Univ, Dept Rheumatol & Immunol, Beijing Shunyi Hosp, Beijing, Peoples R China

[17] Huazhong Univ Sci & Technol, Dept Rheumatol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China

[18] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Rheumatol & Clin Immunol, Guangzhou 510275, Guangdong, Peoples R China

[19] Beijing Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China

[20] Shandong Univ, Dept Rheumatol, Qilu Hosp, Jinan, Shandong, Peoples R China

[21] Cangzhou Hosp Integrated Tradit Chinese & Western, Dept Rheumatol & Immunol, Cangzhou, Hebei, Peoples R China

[22] Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Rheumatol & Immunol, Urumqi, Xinjiang, Peoples R China

[23] Xi An Jiao Tong Univ, Dept Rheumatol & Immunol, Affiliated Hosp 1, Xian 710049, Shaanxi, Peoples R China

[24] Tianjin Med Univ, Dept Infect Dis & Rheumatol, Gen Hosp, Tianjin, Peoples R China

[25] Lanzhou Univ, Dept Rheumatol, Hosp 2, Lanzhou 730000, Gansu, Peoples R China

[26] Beijing Xuanwu Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China

[27] Lanzhou Univ, Dept Rheumatol & Immunol, Affiliated Hosp 5, Lanzhou 730000, Gansu, Peoples R China

[28] 309th Hosp Chinese Peoples Liberat Army, Dept Rheumatol & Immunol, Beijing, Peoples R China

[29] Peking Univ, Dept Clin Epidemiol, Peoples Hosp, Beijing 100044, Peoples R China

来源：

CLINICAL RHEUMATOLOGY | 2015年 / 34卷 / 02期

关键词：

Cross-sectional study; Remission; Rheumatoid arthritis; Risk factors; DRUG-FREE REMISSION; RHEUMATOLOGY/EUROPEAN LEAGUE; RADIOGRAPHIC PROGRESSION; AMERICAN-COLLEGE; CLINICAL REMISSION; DEFINING REMISSION; DISEASE-ACTIVITY; CRITERIA; THERAPY; PREDICTORS;

D O I：

10.1007/s10067-014-2828-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study is to investigate the remission rate of rheumatoid arthritis (RA) in China and identify its potential determinants. A multi-center cross-sectional study was conducted from July 2009 to January 2012. Data were collected by face-to-face interviews of the rheumatology outpatients in 28 tertiary hospitals in China. The remission rates were calculated in 486 RA patients according to different definitions of remission: the Disease Activity Score in 28 joints (DAS28), the Simplified Disease Activity Index (SDAI), the Clinical Disease Activity Index (CDAI), and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean definition. Potential determinants of RA remission were assessed by univariate and multivariate analyses. The remission rates of RA from this multi-center cohort were 8.6 % (DAS28), 8.4 % (SDAI), 8.2 % (CDAI), and 6.8 % (Boolean), respectively. Favorable factors associated with remission were: low Health Assessment Questionnaire (HAQ) score, absence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP), and treatment of methotrexate (MTX) and hydroxychloroquine (HCQ). Younger age was also predictive for the DAS28 and the Boolean remission. Multivariate analyses revealed a low HAQ score, the absence of anti-CCP, and the treatment with HCQ as independent determinants of remission. The clinical remission rate of RA patients was low in China. A low HAQ score, the absence of anti-CCP, and HCQ were significant independent determinants for RA remission.

引用

页码：221 / 230

页数：10

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