Age-related changes in brain proDynorphin gene expression in the rat

被引:17
作者
Kotz, CM
Weldon, D
Billington, CJ
Levine, AS
机构
[1] Vet Affairs Med Ctr, Minneapolis, MN 55417 USA
[2] Minnesota Obes Ctr, Minneapolis, MN 55417 USA
[3] Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN 55108 USA
[4] Univ Minnesota, Dept Psychiat, St Paul, MN 55108 USA
[5] Univ Minnesota, Dept Med, St Paul, MN 55108 USA
[6] Coll Med, Iowa City, IA 52242 USA
关键词
opioids; dynorphin; feeding behavior; brain; aging; aged;
D O I
10.1016/j.neurobiolaging.2004.02.025
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Dynorphin has a well-established role in feeding and gustation. Alterations in taste perception and feeding behavior are common with age. We hypothesized that proDynorphin gene expression in brain areas involved in taste and feeding declines with age. Male Sprague-Dawley rats were housed individually with ad libitum access to food and water. Brain punches of the selected regions were dissected out in groups of rats aged 4-6, 12-14 and 18-21 months. ProDynorphin mRNA (measured using a cDNA probe) decreased significantly with age in arcuate nucleus and amygdala; increased significantly with age in hippocampus; and was not significantly affected in nucleus of the solitary tract, cortex, caudate putamen or hypothalamic paraventricular nucleus. These data suggest an age-related decrease in the synthesis of dynorphin in two brain regions strongly associated with feeding behavior, and an increase in dynorphin synthesis in a brain region associated with learning and memory. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:1343 / 1347
页数:5
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