Innovative approaches in CNS drug discovery

被引：16

作者：

Charveriat, Mathieu ^{[1
]}

Lafon, Vincent ^{[2
]}

Mouthon, Franck ^{[1
]}

Zimmer, Luc ^{[3
,4
]}

机构：

[1] Theranexus, 60 Ave Rockefeller, F-69008 Lyon, France

[2] Insiliance, F-75014 Paris, France

[3] Univ Lyon, F-69675 Lyon, France

[4] Hosp Civils Lyon, F-69500 Bron, France

来源：

THERAPIE | 2021年 / 76卷 / 02期

关键词：

Drug discovery; Biomarker; Central nervous system; Neuropharmacology; Translational; PLURIPOTENT STEM-CELLS; IN-SILICO; DISEASE; MODEL; BIOMARKERS; NEURONS; TRIALS; SCREEN;

D O I：

10.1016/j.therap.2020.12.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Central nervous system disorders remain the leading causes of mortality and morbidity worldwide, affecting more than 1 billion patients. This therapeutic area suffers from high unmet medical needs and the search for innovative approaches to identify therapeutic strategies is urgent in the field. This review will first cover the challenges and opportunities of drug discovery in neurology, and then as well as the new models, such as human model stem cells and animal models under development in the field. In addition, innovative and translational neuroimaging techniques will be discussed, as the use of big data and artificial intelligence to discovery new drugs in neurological and neuropsychiatric disorders. (c) 2020 Societe francaise de pharmacologie et de therapeutique. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：101 / 109

页数：9

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