Antigen-Specific Culture of Memory-like CD8 T Cells for Adoptive Immunotherapy

被引：5

作者：

Litterman, Adam J. ^{[1
,2
,3
]}

Zellmer, David M. ^{[1
,2
,3
]}

LaRue, Rebecca S. ^{[1
,4
,6
]}

Jameson, Stephen C. ^{[5
,7
]}

Largaespada, David A. ^{[1
,2
,3
,4
,6
]}

机构：

[1] Univ Minnesota, Mason Canc Res Ctr, Minneapolis, MN 55455 USA

[2] Univ Minnesota, BrainTumor Program, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

[5] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[6] Univ Minnesota, Ctr Genome Engn, Minneapolis, MN 55455 USA

[7] Univ Minnesota, Ctr Immunol, Minneapolis, MN 55455 USA

来源：

CANCER IMMUNOLOGY RESEARCH | 2014年 / 2卷 / 09期

关键词：

DIFFERENTIATION; GENERATION; RESPONSES; FOXM1;

D O I：

10.1158/2326-6066.CIR-14-0038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytotoxic T cells typically are expanded ex vivo in culture with IL2 for adoptive immunotherapy. This culture period leads to a differentiated phenotype and acquisition of effector function, as well as a loss of in vivo proliferative capability and antitumor efficacy. Here, we report antigen-specific and polyclonal expansion of cytotoxic T cells in a cocktail of cytokines and small molecules that leads to a memory-like phenotype in mouse and human cells even during extended culture, leading to enhanced in vivo expansion and tumor control in mice.

引用

页码：839 / 845

页数：7

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