Contribution of Interleukin-10 Genotype to Triple Negative Breast Cancer Risk

被引：13

作者：

CHEN, KAI-YUAN ^{[1
,2
,3
]}

CHIEN, WEI-CHING ^{[4
]}

LIAO, JIUAN-MIAW ^{[5
,6
]}

TSAI, CHIA-WEN ^{[1
,7
]}

CHANG, WEN-SHIN ^{[1
,7
]}

SU, CHEN-HSIEN ^{[7
]}

HSU, SHIH-WEI ^{[1
,7
]}

WANG, HWEI-CHUNG ^{[8
]}

BAU, DA-TIA ^{[1
,7
,9
]}

机构：

[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[2] Taichung Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Taichung, Taiwan

[3] Natl Def Med Ctr, Sch Med, Taipei, Taiwan

[4] Chang Bing Show Chwan Mem Hosp, Cell Therapy Ctr, Changhua, Taiwan

[5] Chung Shan Med Univ, Dept Physiol, Taichung, Taiwan

[6] Chung Shan Med Univ Hosp, Taichung, Taiwan

[7] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, Taichung, Taiwan

[8] China Med Univ Hosp, Dept Breast Surg, Taichung, Taiwan

[9] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

来源：

ANTICANCER RESEARCH | 2021年 / 41卷 / 05期

关键词：

Breast cancer; genotype; interleukin-10; polymorphism; Taiwan; PROMOTER POLYMORPHISM; GASTRIC-CANCER; GENE POLYMORPHISM; ASSOCIATION; SUSCEPTIBILITY; REGION; EXPRESSION;

D O I：

10.21873/anticanres.15020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Triple negative breast cancer (TNBC) is characterized by increased recurrence and poor survival. Mounting evidence suggests that interleukin-10 (IL-10) plays a role in carcinogenesis, however, little is known about the contribution of IL-10 to TNBC. The study evaluated the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genotypes to the risk of TNBC. Materials and Methods: IL-10 genotypes were examined among 1,232 breast cancer patients and 1,232 controls and evaluated. Results: The percentages of AG and GG for IL-10 A 1082G genotypes were higher in the breast cancer patient group than in the control group. The GG genotype carriers were of higher risk for breast cancer [odds ratio (OR)=2.02, 95% confidence interval (CI)=1.28-3.21, p=0.0021]. Interestingly, G allele carriers were of higher risk of TNBC (OR=1.25, 95%CI=1.07-1.46, p=0.0050). Conclusion: The G allele of IL 10 A-1082G genotype may serve as a predictor for TNBC risk. The finding should be validated in other populations.

引用

页码：2451 / 2457

页数：7

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