Design and evaluation of topical solid dispersion composite of voriconazole for the treatment of ocular keratitis

被引：4

作者：

Patil, Monali ^{[1
]}

Waydande, Swati ^{[1
]}

Pawar, Pravin ^{[2
]}

机构：

[1] Gourishankar Inst Pharmaceut Educ & Res, Dept Pharmaceut PG, Survey 990,NH-4, Satara 4150415, Maharashtra, India

[2] Annasaheb Dange Coll B Pharm, Dept Pharmaceut, Sangli 415301, Maharashtra, India

来源：

THERAPEUTIC DELIVERY | 2019年 / 10卷 / 08期

关键词：

ocular keratitis; PVPK-90; solid dispersion; transcorneal permeation; voriconazole; IN-VITRO PERMEATION; FORMULATION FACTORS; CORNEAL PERMEABILITY; EXCISED GOAT; RELEASE; TROMETHAMINE; KETOROLAC; DROPS; ACID;

D O I：

10.4155/tde-2019-0021

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: The objective of present investigation was to increases solubility of voriconazole by using solid dispersion techniques and the development of solid dispersion-based voriconazole ophthalmic solutions. Materials & methods: The saturation solubility of solid dispersion containing polyvinylpyrrolidone K90 (PVPK-90) was found to increase the solubility of voriconazole compare other carrier like polyethylene glycol and Polyvinylpyrrolidone K 30 (PVPK-30). Solid dispersion of voriconazole was characterized by saturation solubility, Fourier-transform infrared spectroscopy and Differential scanning calorimetry study. Results & conclusion: The Fourier-transform infrared spectroscopy and Differential scanning calorimetry studies of voriconazole-based solid dispersion confirmed the complete changes in original polymorphic form of voriconazole. The antifungal assay showed that the maximum zone of inhibition was produced from optimized ophthalmic formulation containing sodium alginate as compared with other formulations and marketed eye drops.

引用

页码：481 / 492

页数：12

共 29 条

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[2]

Ahmad Z., 2011, International Journal of Pharmacy Technology, P807

[3] Effect of formulation factors on in vitro permeation of diclofenac from experimental and marketed aqueous eye drops through excised goat cornea [J].