Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada

被引：60
作者：
Tijet, Nathalie [1 ]
Faccone, Diego [2 ,3 ]
Rapoport, Melina [2 ]
Seah, Christine [1 ]
Pasteran, Fernando [2 ]
Ceriana, Paola [2 ]
Albornoz, Ezequiel [2 ]
Corso, Alejandra [2 ]
Petroni, Alejandro [2 ]
Melano, Roberto G. [1 ,4 ]
机构：
[1] Publ Hlth Ontario Lab, Toronto, ON, Canada
[2] Inst Nacl Enfermedades Infecciosas INEI ANLIS Dr, Serv Antimicrobianos, Natl & Reg Reference Lab Antimicrobial Resistance, Buenos Aires, DF, Argentina
[3] Consejo Nacl Invest Cient & Tecn CONICET, Buenos Aires, DF, Argentina
[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
来源：
PLOS ONE | 2017年 / 12卷 / 07期
关键词：
RESISTANCE GENE MCR-1; ENTEROBACTERIACEAE; MECHANISMS; STRAIN;
D O I：
10.1371/journal.pone.0180347
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these plasmids carried a mcr-1-variant called here mcr-1.5. All these E. coli isolates were not clonally related and were recovered in different years and locations. However, their mcr-1-harboring plasmids showed high identity among them and to others characterized in other countries, which strongly suggests that this plasmid-type is playing an important role in spreading this mechanism of resistance to polymyxins.
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