Triptycene-derived heterocalixarene: A new type of macrocycle-based stationary phases for gas chromatography

This work reports the investigation of a new triptycene-derived oxacalixarene (TDOC) as the stationary phase for gas chromatography (GC) with high-resolution performance for a wide range of analytes and isomers. The TDOC scaffold is composed of triptycene and 1,8-naphthyridine moieties, inherently differing from the conventional calixarenes in structures and properties. As a result, the TDOC column exhibited outstanding column efficiency of 5679 plates/m by n-dodecane at 120 degrees C. It showed advantageous performance for separations of the mixtures with various analytes and achieved high resolution of diverse isomers (skeletal, positional and cis-/trans-isomers) from apolar to polar nature. Moreover, the TDOC column exhibited high thermal stability up to 310 degrees C. To date, the TDOC-based materials have not been reported in chromatography. This work demonstrates the good potential of the triptycene-derived heterocalixarenes as a new class of stationary phases for chromatographic analyses. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.