A multidisciplinary study of chemico-physical properties of different classes of 2-aryl-5(or 6)-nitrobenzimidazoles: NMR, electrochemical behavior, ESR, and DFT calculations

被引：4

作者：

Rakib, El Mostapha ^{[1
]}

Boga, Carla ^{[2
]}

Calvaresi, Matteo ^{[3
]}

Chigr, Mohamed ^{[1
]}

Franchi, Paola ^{[3
]}

Gualandi, Isacco ^{[2
]}

Ihammi, Aziz ^{[1
]}

Lucarini, Marco ^{[3
]}

Micheletti, Gabriele ^{[2
]}

Spinelli, Domenico ^{[3
]}

Tonelli, Domenica ^{[2
]}

机构：

[1] Sultan Moulay Slimane Univ, Fac Sci & Tech, Lab Organ & Analyt Chem, BP 523, Beni Mellal 2300, Morocco

[2] Univ Bologna, Dept Ind Chem Toso Montanari Alma Mater Studiorum, Viale Risorgimento 4, I-40136 Bologna, Italy

[3] Univ Bologna, Dept Chem G Ciamician Alma Mater Studiorum, Via Selmi 2, I-40126 Bologna, Italy

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2021年 / 14卷 / 06期

关键词：

2-Aryl-nitrobenzimidazoles; H-1 and C-13 NMR; Cyclic voltammetry; Electron spin resonance; DFT calculations; BENZIMIDAZOLE DERIVATIVES; IN-VITRO; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; CRYSTAL-STRUCTURE; RADICAL-ANIONS; INHIBITION; REDUCTION; ANALOGS;

D O I：

10.1016/j.arabjc.2021.103179

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Continuing in our researches on the syntheses, reactivity, pharmacological/biological activities of heterocyclic compounds containing one or more nitrogen atoms we have examined some chemico-physical properties (H-1 and C-13 NMR, electrochemical behavior, and ESR) of three series of 2-aryl-5(or 6)-nitrobenzimidazoles (1-3) variously substituted in the 2-aryl ring. The electrochemical behavior of the nitro group on the benzimidazole ring has been studied by cyclic voltammetry. This has allowed to point out both the reversibility, the formal potential, and the number of electrons involved in the electrochemical processes, and to evaluate the effect of the substituents present on the aryl ring. The data collected have been able to furnish a complete picture of electronic distribution and have been supported by DFT calculations. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of King Saud University.

引用

页数：14

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