Invadopodia: proteolytic feet of cancer cells

被引：5

作者：

Bati, Gizem ^{[1
]}

Pesen Okvur, Devrim ^{[2
]}

机构：

[1] Izmir Inst Technol, Grad Program Biotechnol & Bioengn, Izmir, Turkey

[2] Izmir Inst Technol, Dept Mol Biol & Genet, Izmir, Turkey

来源：

TURKISH JOURNAL OF BIOLOGY | 2014年 / 38卷 / 06期

关键词：

Metastasis; invadopodia; GROWTH-FACTOR RECEPTOR; EXTRACELLULAR-MATRIX DEGRADATION; N-WASP; REGULATES COFILIN; CORTACTIN; INVASION; INTEGRIN; EXPRESSION; PODOSOMES; PHOSPHORYLATION;

D O I：

10.3906/biy-1404-110

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The leading cause of death in cancer patients is metastasis. Invasion is an integral part of metastasis and is carried out by proteolytic structures called invadopodia at the cellular level. In this introductory review, we start by evaluating the definition of invadopodia. While presenting the upstream signaling events involved, we integrate current models on invadopodia. In addition, we discuss the significance of invadopodia in 2D and 3D and in vivo. We finally point out technical challenges and conclude with open questions in the field.

引用

页码：740 / 747

页数：8

共 72 条

[1] The integrin - Growth factor receptor duet [J].

Alam, Naved ;

Goel, Hira Lal ;

Zarif, Matthew J. ;

Butterfield, Julie E. ;

Perkins, Hillary M. ;

Sansoucy, Brian G. ;

Sawyer, Thomas K. ;

Languino, Lucia R. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 213 (03) :649-653

[2] Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: Defining the stages of invadopodia formation and function [J].

Artym, VV ;

Zhang, Y ;

Seillier-Moiseiwitsch, FO ;

Yamada, KM ;

Mueller, SC .

CANCER RESEARCH, 2006, 66 (06) :3034-3043

[3] Invadopodia: A guided tour [J].

Ayala, I ;

Baldassarre, M ;

Caldieri, G ;

Buccione, R .

EUROPEAN JOURNAL OF CELL BIOLOGY, 2006, 85 (3-4) :159-164

[4] Faciogenital Dysplasia Protein Fgd1 Regulates Invadopodia Biogenesis and Extracellular Matrix Degradation and Is Up-regulated in Prostate and Breast Cancer [J].

Ayala, Inmaculada ;

Giacchetti, Giada ;

Caldieri, Giusi ;

Attanasio, Francesca ;

Mariggio, Stefania ;

Tete, Stefano ;

Polishchuk, Roman ;

Castronovo, Vincent ;

Buccione, Roberto .

CANCER RESEARCH, 2009, 69 (03) :747-752

[5] Dynamin participates in focal extracellular matrix degradation by invasive cells [J].

Baldassarre, M ;

Pompeo, A ;

Beznoussenko, G ;

Castaldi, C ;

Cortellino, S ;

McNiven, MA ;

Luini, A ;

Buccione, R .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (03) :1074-1084

[6] β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation [J].

Beaty, Brian T. ;

Sharma, Ved P. ;

Bravo-Cordero, Jose J. ;

Simpson, Mark A. ;

Eddy, Robert J. ;

Koleske, Anthony J. ;

Condeelis, John .

MOLECULAR BIOLOGY OF THE CELL, 2013, 24 (11) :1661-1675

[7] A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo [J].

Blouw, Barbara ;

Seals, Darren F. ;

Pass, Ian ;

Diaz, Begona ;

Courtneidge, Sara A. .

EUROPEAN JOURNAL OF CELL BIOLOGY, 2008, 87 (8-9) :555-567

[8] Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells [J].

Bowden, ET ;

Onikoyi, E ;

Slack, R ;

Myoui, A ;

Yoneda, T ;

Yamada, KM ;

Mueller, SC .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (08) :1240-1253

[9] An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation [J].

Bowden, ET ;

Barth, M ;

Thomas, D ;

Glazer, RI ;

Mueller, SC .

ONCOGENE, 1999, 18 (31) :4440-4449

[10] Directed cell invasion and migration during metastasis [J].

Bravo-Cordero, Jose Javier ;

Hodgson, Louis ;

Condeelis, John .

CURRENT OPINION IN CELL BIOLOGY, 2012, 24 (02) :277-283

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