Construction of silver nanoparticles anchored flower-like magnetic Fe3O4@SiO2@MnO2 hybrids with antibacterial and wound healing activity

With the increased risk of wound infection caused by pathogenic bacteria, silver nanoparticles have been considered as potential antibacterial nanosystem. However, the challenge of size control and agglomeration of silver nanoparticles need to be considered. Herein, the application of flower-like silver nanoparticles (Ag NPs) anchored Fe3O4@SiO2@MnO2 hybrids (Ag/FSM) in the control of pathogenic bacteria and promotion of wound healing were reported. TEM results indicated the ultrafine Ag NPs were uniformly dispersed onto the surface of FSM. In vitro experimental results showed the Minimum inhibitory concentration (MIC) of Ag/FSM against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were 60 and 100 mu g mL-1, respectively. Furthermore, in vivo investigation in mice demonstrated that the hybrids showed low toxicity and effectively promoted wound healing caused by the infection of E. coli. In summary, the results supported the possibility that Ag/FSM could be considered as an antibacterial agent with potential for the treatment of bacterial infections.