Impact of Lymph Node Metastases Around the Superior Mesenteric Artery on Postoperative Outcomes of Pancreatic Head Cancer

被引：2

作者：

Miyata, Yoichi ^{[1
]}

Yonamine, Naoto ^{[1
]}

Fujinuma, Ibuki ^{[1
]}

Tsunenari, Takazumi ^{[1
]}

Takihata, Yasuhiro ^{[1
]}

Iwasaki, Toshimitsu ^{[1
]}

Einama, Takahiro ^{[1
]}

Tsujimoto, Hironori ^{[1
]}

Ueno, Hideki ^{[1
]}

Yamamoto, Junji ^{[2
]}

Kishi, Yoji ^{[1
]}

机构：

[1] Natl Def Med Coll Hosp, Dept Surg, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan

[2] Ibaraki Cent Hosp, Dept Gastrointestinal Surg, Ibaraki 3091793, Japan

来源：

WORLD JOURNAL OF SURGERY | 2021年 / 45卷 / 12期

关键词：

EXTENDED LYMPHADENECTOMY; NERVE PLEXUS; ADENOCARCINOMA; PANCREATICODUODENECTOMY; STANDARD; DISSECTION; CARCINOMA; RESECTION; SURVIVAL; PATTERN;

D O I：

10.1007/s00268-021-06276-0

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background The neural plexus and lymph nodes around the superior mesenteric artery (LN#14), are the most frequent sites involved by pancreatic head cancer. However the influence of metastases to LN#14 on patients' prognosis has rarely been evaluated. Methods The patients who underwent pancreatectomy for pancreatic head cancer between January 2010 and December 2018 were selected. The patients with nodal metastases were classified into an LN#14 + or LN#14-group according to LN#14 metastasis. Clinical and pathological characteristics and prognosis were compared between the two groups. Results In total, 99 patients underwent pancreatectomy. Ninety-four patients were positive for lymph node metastases and 14 and 80 were classified as LN#14 + and LN#14 - , respectively. Postoperative median overall survival (OS) of the LN#14 + and LN#14 - groups was 10.2 and 31.1 months, respectively (P < 0.001). Median OS of the LN#14 + group was worse than that of patients with >= 4 metastatic nodes in the LN#14 - group (n = 35, 24.7 months, P = 0.002). In multivariate analysis, LN#14 + (hazard ratio [HR] = 3.89, 95% confidence interval [CI], 1.64-8.86) was one of the independent predictors of worse OS. Conclusion It might be feasible to recognize LN#14 metastases as an important prognostic factor independently from other regional lymph node metastases.

引用

页码：3668 / 3676

页数：9

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