Formation of iron-sulfur clusters in bacteria: an emerging field in bioinorganic chemistry

被引：184

作者：

Frazzon, J ^{[1
]}

Dean, DR

机构：

[1] Univ Fed Rio Grande do Sul, Dept Food Sci, ICTA, BR-91051970 Porto Alegre, RS, Brazil

[2] Virginia Tech, Dept Biochem, Blacksburg, VA 24060 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(03)00021-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biological iron-sulfur clusters are chemically versatile inorganic structures that are attached to many proteins. These clusters are intimately involved in the functions of their partner proteins and they are required to sustain life on earth. Recent work has demonstrated that, in spite of their simple structures, the assembly and insertion of iron-sulfur clusters into their protein partners is a complex biological process. This complexity is probably related to the cellular toxicity of iron and sulfur in their free forms.

引用

页码：166 / 173

页数：8

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