What does 'chromatin remodeling' mean?

被引：155

作者：

Aalfs, JD ^{[1
]}

Kingston, RE

机构：

[1] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 11期

关键词：

D O I：

10.1016/S0968-0004(00)01689-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulated alteration of chromatin structure, termed 'chromatin remodeling', can be accomplished by covalent modification of histones or by the action of ATP-dependent remodeling complexes. A variety of mechanisms can be used to remodel chromatin; some act locally on a single nucleosome and others act more broadly. It is critical to establish a direct connection between the remodeling events observed in vivo and the mechanistic capabilities of remodeling complexes in vitro.

引用

页码：548 / 555

页数：8

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