Therapeutic advances of miRNAs: A preclinical and clinical update

被引：283

作者：

Chakraborty, Chiranjib ^{[1
,2
]}

Sharma, Ashish Ranjan ^{[2
]}

Sharma, Garima ^{[3
]}

Lee, Sang-Soo ^{[2
]}

机构：

[1] Adamas Univ, Sch Life Sci & Biotechnol, Dept Biotechnol, Barasat Barrackpore Rd, Kolkata 700126, W Bengal, India

[2] Hallym Univ, Chuncheon Sacred Heart Hosp, Inst Skeletal Aging & Orthoped Surg, Chunchon 24252, Gangwon Do, South Korea

[3] Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon 24341, South Korea

来源：

JOURNAL OF ADVANCED RESEARCH | 2021年 / 28卷

基金：

新加坡国家研究基金会;

关键词：

miRNA; Next-generation medicine; Biopharmaceuticals; SYSTEMIC ENERGY HOMEOSTASIS; MICRORNA DELIVERY; DEGRADABLE DENDRIMERS; INSULIN-RESISTANCE; PANCREATIC-CANCER; DRUG-METABOLISM; EMERGING ROLE; HEPATITIS-C; SMALL RNAS; MIR-34A;

D O I：

10.1016/j.jare.2020.08.012

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. Aim of the Review: A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. Key Scientific Concepts of Review: In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

引用

页码：127 / 138

页数：12

共 110 条

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