Recent Advances in the Synthesis and Chemistry of Nitronates

Due to their availability and versatile reactivity, nitronates have become important building blocks in the stereoselective synthesis of bioactive molecules. This short review provides a summary of recent developments on the synthesis, chemistry and applications of O-alkyl and O-silyl nitronates. Introduction Approaches to the Synthesis of Nitronates Synthesis of Six- Membered Cyclic Nitronates Formal [4+ 2] Approaches Formal [3+ 3] Approaches Other Approaches Synthesis of Five-Membered Cyclic Nitronates Formal [3+ 2] Approaches Formal [4+ 1] Approaches Oxidation Approaches Chemistry of Nitronates Nitronates as alpha-C-Nucleophiles Nitronates as alpha-C-Electrophiles Nitronates in [3+ n]-AnnulationReactions Reactions Involving the beta-Carbon Atom of Nitronates Miscellaneous Transformations Conclusion