Hyperthermia and Controllable Free Radical Coenhanced Synergistic Therapy in Hypoxia Enabled by Near-Infrared-II Light Irradiation

被引：131
作者：
Yang, Jun [1 ]
Xie, Rui [2 ,3 ,4 ]
Feng, Lili [2 ,5 ]
Liu, Bin [5 ]
Lv, Ruichan [5 ]
Li, Chunxia [2 ]
Gai, Shili [5 ]
He, Fei [5 ]
Yang, Piaoping [5 ]
Lin, Jun [2 ]
机构：
[1] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130021, Jilin, Peoples R China
[3] Harbin Med Univ, Canc Hosp, Dept Digest Internal Med, Harbin 150081, Heilongjiang, Peoples R China
[4] Harbin Med Univ, Canc Hosp, Photodynam Therapy Ctr, Harbin 150081, Heilongjiang, Peoples R China
[5] Harbin Engn Univ, Key Lab Superlight Mat & Surface Technol, Coll Mat Sci & Chem Engn, Minist Educ, Harbin 150001, Heilongjiang, Peoples R China
来源：
ACS NANO | 2019年 / 13卷 / 11期
基金：
中国国家自然科学基金;
关键词：
free radicals; hypoxia; oxygen-independent; photothermal; second near-infrared window; CuFeSe2; UP-CONVERSION NANOPARTICLES; VIVO PHOTODYNAMIC THERAPY; CONTROLLED DRUG-RELEASE; CANCER-THERAPY; IRON-OXIDE; POLYPYRROLE NANOPARTICLES; TUMOR; GENERATION; ALBUMIN; NANOPLATFORM;
D O I：
10.1021/acsnano.9b05985
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tumor cell metabolism and tumor blood vessel proliferation are distinct from normal cells. The resulting tumor microenvironment presents a characteristic of hypoxia, which greatly limits the generation of oxygen free radicals and affects the therapeutic effect of photo dynamic therapy. Here, we developed an oxygen-independent free radical generated nanosystem (CuFeSe2-AIPH@BSA) with dual-peak absorption in both near-infrared (NIR) regions and utilized it for imaging-guided synergistic treatment. The special absorption provides the nanosystem with high photothermal conversion efficiency and favorably matched photoactivity in both I and II NIR biological windows. Upon NIR light irradiation, the generated heat could prompt AIPH release and decompose to produce oxygen-independent free radicals for killing cancer cells effectively. The contrastive research results show that the enhanced therapeutic efficacy of NIR-II over NIR-I is principally due to its deeper tissue penetration and higher maximum permission exposure that benefits from a longer wavelength. Hyperthermia effect and the production of toxic free radicals upon NIR-II laser illumination are extremely effective in triggering apoptosis and death of cancer cells in the tumor hypoxia microenvironment. The high biocompatibility and excellent anticancer efficiency of CuFeSe2-AIPH@BSA allow it to be an ideal oxygen-independent nanosystem for imaging-guided and NIR-II-mediated synergistic therapy via systemic administration.
引用
收藏
页码：13144 / 13160
页数：17
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