The Intestinal Immune System in Obesity and Insulin Resistance

被引：408
作者：
Winer, Daniel A. [1 ,2 ,3 ,4 ,6 ]
Luck, Helen [1 ,2 ,6 ]
Tsai, Sue [1 ,6 ]
Winer, Shawn [1 ,3 ,5 ,6 ]
机构：
[1] Univ Hlth Network, Toronto Gen Res Inst, Div Cellular & Mol Biol, Diabet Res Grp, 101 Coll St, Toronto, ON M5G 1L7, Canada
[2] Univ Toronto, Dept Immunol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada
[3] Univ Toronto, Dept Lab Med & Pathobiol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada
[4] Univ Hlth Network, Dept Pathol, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada
[5] St Michaels Hosp, Dept Lab Med, 30 Bond St, Toronto, ON M5B 1W8, Canada
[6] 10-352 Toronto Med Discovery Tower,101 Coll St, Toronto, ON M5G 1L7, Canada
来源：
CELL METABOLISM | 2016年 / 23卷 / 03期
关键词：
DIET-INDUCED OBESITY; REGULATORY T-CELLS; INNATE LYMPHOID-CELLS; GUT MICROBIOTA; METABOLIC ENDOTOXEMIA; INDUCED INFLAMMATION; DENDRITIC CELLS; ORAL-TOLERANCE; TNF-ALPHA; ADIPOSE;
D O I：
10.1016/j.cmet.2016.01.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Obesity and insulin resistance are associated with chronic inflammation in metabolic tissues such as adipose tissue and the liver. Recently, growing evidence has implicated the intestinal immune system as an important contributor to metabolic disease. Obesity predisposes to altered intestinal immunity and is associated with changes to the gut microbiota, intestinal barrier function, gut-residing innate and adaptive immune cells, and oral tolerance to luminal antigens. Accordingly, the gut immune system may represent a novel therapeutic target for systemic inflammation in insulin resistance. This review discusses the emerging field of intestinal immunity in obesity-related insulin resistance and how it affects metabolic disease.
引用
收藏
页码：413 / 426
页数：14
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