Essential Oils from Different Myrtaceae Species from Brazilian Atlantic Forest Biome - Chemical Dereplication and Evaluation of Antitrypanosomal Activity

被引：7

作者：

Silva Maiolini, Tatiane Cristina ^{[1
]}

Rosa, Welton ^{[1
]}

Miranda, Daniel Oliveira ^{[1
]}

Costa-Silva, Thais A. ^{[2
]}

Tempone, Andre G. ^{[3
]}

Pires Bueno, Paula Carolina ^{[1
]}

Dias, Danielle Ferreira ^{[1
]}

Chagas de Paula, Daniela Aparecida ^{[1
]}

Sartorelli, Patricia ^{[4
]}

Lago, Joao Henrique G. ^{[2
]}

Soares, Marisi Gomes ^{[1
]}

机构：

[1] Univ Fed Alfenas, Inst Chem, BR-37130001 Alfenas, MG, Brazil

[2] Univ Fed ABC, Ctr Nat Sci & Humanities, BR-09210580 Santo Andre, SP, Brazil

[3] Ctr Parasitol & Mycol, Inst Adolfo Lutz, BR-01246902 Sao Paulo, SP, Brazil

[4] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, BR-09913030 Diadema, SP, Brazil

来源：

CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 06期

基金：

瑞典研究理事会; 巴西圣保罗研究基金会;

关键词：

Myrtaceae; essential oils; dereplication; Trypanosoma cruzi; multivariate analysis; O; BERG; LEAVES; FLOWERS;

D O I：

10.1002/cbdv.202200198

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chagas Disease (CD), caused by flagellate protozoan Trypanosoma cruzi, is a Neglected Tropical Diseases (NTD) that affect approximately seven million people worldwide with a restrict therapeutical arsenal. In the present study, the essential oils from 18 Myrtaceae species were extracted, chemically dereplicated, and evaluated in vitro against T. cruzi. From these, eight essential oils were considered promising (IC(50)10) against the protozoan: Eugenia florida, E. acutata, E. widgrenii, Calyptranthes brasilienses, C. widgreniana, Plinia cauliflora, Campomanesia xanthocarpa, and Psidium guajava. Multivariate data analysis pointed out (E)-caryophyllene, alpha-humulene, limonene, caryophyllene oxide, and alpha-copaene playing an important role in the anti-T. cruzi activity. The obtained results demonstrated the potential of essential oils of Myrtaceae species as valuable sources of bioactive compounds against T. cruzi.

引用

页数：13

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