Large gain in translational entropy of water is a major driving force in protein folding

被引：88

作者：

Harano, Y ^{[1
]}

Kinoshita, M ^{[1
]}

机构：

[1] Kyoto Univ, Inst Adv Energy, Uji, Kyoto 6110011, Japan

来源：

CHEMICAL PHYSICS LETTERS | 2004年 / 399卷 / 4-6期

关键词：

D O I：

10.1016/j.cplett.2004.09.140

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A view lacking in earlier studies on protein folding is that the process is critically influenced by the thermal motion of water molecules. Here it is pointed out that there is a powerful driving force, a large gain in the translational entropy (TE) of water, which competes with the large loss of the conformational entropy in the folding. We analyze the TE of water in which a protein molecule with a prescribed conformation is immersed. We consider a number of conformations and show that the largest TE is attained only in the native structure. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：342 / 348

页数：7

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