Asymmetric Synthesis of Indolines Bearing a Benzylic Quaternary Stereocenter through Intramolecular Arylcyanation of Alkenes

被引：43

作者：

Hsieh, Jen-Chieh ^{[1
]}

Ebata, Shiro ^{[1
]}

Nakao, Yoshiaki ^{[1
]}

Hiyama, Tamejiro ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Kyoto 6158510, Japan

来源：

SYNLETT | 2010年 / 11期

关键词：

asymmetric synthesis; carbocyanation; C-C bond activation; nickel; indoline; CYCLIZATION-ANION CAPTURE; HECK REACTION; PALLADIUM; CYANOAMIDATION; ANALOGS;

D O I：

10.1055/s-0029-1219964

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective intramolecular arylcyanation of olefins is achieved by a Ni(cod)(2)/chiral phosphinoxazoline/AlMe(2)Cl catalyst to give chiral, substituted indoline derivatives bearing a benzylic quaternary stereocenter in high yields with good to excellent enantioselectivities.

引用

页码：1709 / 1711

页数：3

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