The Impact of Prior Authorization on Buprenorphine Dose, Relapse Rates, and Cost for Massachusetts Medicaid Beneficiaries with Opioid Dependence

ObjectiveTo assess the impact of a 2008 dose-based prior authorization policy for Massachusetts Medicaid beneficiaries using buprenorphine+naloxone for opioid addiction treatment. Doses higher than 16mg required progressively more frequent authorizations. Data SourcesMediciaid claims for 2007 and 2008 linked with Department of Public Health (DPH) service records. Study DesignWe conducted time series for all buprenorphine users and a longitudinal cohort analysis of 2,049 individuals who began buprenorphine treatment in 2007. Outcome measures included use of relapse-related services, health care expenditures per person, and buprenorphine expenditures. Data Collection/Extraction MethodsWe used ICD-9 codes and National Drug Codes to identify individuals with opioid dependence who filled prescriptions for buprenorphine. Medicaid and DPH data were linked with individual identifiers. Principal FindingsIndividuals using doses >24mg decreased from 16.5 to 4.1 percent. Relapses increased temporarily for some users but returned to previous levels within 3months. Buprenorphine expenditures decreased but total expenditures did not change significantly. ConclusionPrior authorization policies strategically targeted by dose level appear to successfully reduce use of higher than recommended buprenorphine doses. Savings from these policies are modest and may be accompanied by brief increases in relapse rates. Lower doses may decrease diversion of buprenorphine.