Preliminary evidence for an increased likelihood of a stable trajectory in mild cognitive impairment in individuals with higher motivational abilities

被引:4
作者
Thoma, Myriam, V [1 ,2 ,13 ]
Forstmeier, Simon [1 ,3 ]
Schmid, Roger [4 ]
Kellner, Oliver [5 ,6 ]
Xepapadakos, Franziskos [7 ]
Gasser, Ursula Schreiter [8 ]
Blessing, Andreas [9 ]
Ropohl, Axel [10 ,11 ]
Bieri-Bruning, Gabriela [12 ]
Debeer, Dries [1 ]
Maercker, Andreas [1 ,2 ]
机构
[1] Univ Zurich, Binzmuehlestr 14, CH-8050 Zurich, Switzerland
[2] Univ Zurich, Univ Res Prior Program Dynam Hlth Aging, Zurich, Switzerland
[3] Univ Siegen, Fac 2, Dev Psychol, Adolf Reichwein Str 2, D-57068 Siegen, Germany
[4] Psychiat Klin Zugersee, Zug, Switzerland
[5] Integrierte Psychiat Winterthur, Winterthur, Switzerland
[6] Alterspsychiat Praxis, Buehlach, Switzerland
[7] Clienia Schloessli AG, Oetwil Am See, Switzerland
[8] Praxis Psychiat Rehalp, Zurich, Switzerland
[9] Psychiat Dienste Thurgau, Muensterlingen, Switzerland
[10] Sanat Kilchberg AG, Kilchberg, Switzerland
[11] KMG Kompetenz Mentale Gesundheit GmbH, Baar, Switzerland
[12] Geriatr Serv City Zurich, Zurich, Switzerland
[13] Univ Zurich, Psychopathol & Clin Intervent, Binzmuehlestr 14-17, CH-8050 Zurich, Switzerland
基金
瑞士国家科学基金会;
关键词
Mild cognitive impairment; Stability; Informant-rated motivational abilities; ALZHEIMERS ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; PHYSICAL-ACTIVITY; SELF-EFFICACY; BRAIN RESERVE; DEMENTIA; DISEASE; DEPRESSION; RECOMMENDATIONS;
D O I
10.1186/s12877-018-0865-5
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: Motivational abilities (MA), that describe skills in relation to goal-oriented behavior, have recently been found to be associated with neuropathological aging. Here we examine the impact of MA on the long-term course of mild cognitive impairment (MCI). Methods: We followed-up N = 64 individuals diagnosed with MCI (M-age = 73 years, 44% female) for 3 years. MA were assessed by long-term informants of the participants using two scales: motivation and decision regulation [Volitional Components Questionnaires, VCQ, (Kuhl and Fuhrmann, Decomposing self-regulation and self-control: the volitional components inventory, 1998)]. Cognitive abilities were assessed with the Mini Mental State Examination (J Psychiatr Res 12:189-98, 1975). Survival analyses and multilevel modeling (MLM) were applied to determine the predicting effect of informant-rated MA at baseline on the likelihood of MCI stability and on the trajectory of cognitive abilities. Results: Fifty percent (n = 32) of the MCI participants remained stable, while 32.8% (n = 21) and 17.2% (n = 11) converted to Alzheimer's disease (AD) or dropped-out, respectively. Survival analyses revealed that MCI cases with higher-rated MA at baseline were more likely to exert a stable course in MCI over 3 years (p = 0.036) when controlling for demographic characteristics and executive function. MLM analyses indicated that higher informant rated MA at baseline were significantly related to higher cognitive abilities, even when controlling for MCI subtype (p = 0.030). Conclusions: This study provides preliminary longitudinal evidence for a lower risk of conversion to AD and higher cognitive abilities by higher rated MA at an early stage of MCI.
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页数:17
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共 73 条
  • [1] The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Albert, Marilyn S.
    DeKosky, Steven T.
    Dickson, Dennis
    Dubois, Bruno
    Feldman, Howard H.
    Fox, Nick C.
    Gamst, Anthony
    Holtzman, David M.
    Jagust, William J.
    Petersen, Ronald C.
    Snyder, Peter J.
    Carrillo, Maria C.
    Thies, Bill
    Phelps, Creighton H.
    [J]. ALZHEIMERS & DEMENTIA, 2011, 7 (03) : 270 - 279
  • [2] The aging brain: The cognitive reserve hypothesis and hominid evolution
    Allen, JS
    Bruss, J
    Damasio, H
    [J]. AMERICAN JOURNAL OF HUMAN BIOLOGY, 2005, 17 (06) : 673 - 689
  • [3] American Psychiatric Association, 2013, DIAGN STAT MAN MENT, DOI [DOI 10.1176/APPI.BOOKS.9780890425596, 10.1176/appi.books.9780890425596]
  • [4] Resistance vs resilience to Alzheimer disease Clarifying terminology for preclinical studies
    Arenaza-Urquijo, Eider M.
    Vemuri, Prashanthi
    [J]. NEUROLOGY, 2018, 90 (15) : 695 - 703
  • [5] Baltes MargretM., 1990, SUCCESSFUL AGING, P1, DOI [DOI 10.1017/CBO9780511665684, 10.4324/9781315245706-13, DOI 10.1017/CBO9780511665684.003]
  • [6] Bandura A., 1977, SOCIAL LEARNING THEO
  • [7] Number of Children and Telomere Length in Women: A Prospective, Longitudinal Evaluation
    Barha, Cindy K.
    Hanna, Courtney W.
    Salvante, Katrina G.
    Wilson, Samantha L.
    Robinson, Wendy P.
    Altman, Rachel M.
    Nepomnaschy, Pablo A.
    [J]. PLOS ONE, 2016, 11 (01):
  • [8] Toward a better understanding of the influences on physical activity - The role of determinants, correlates, causal variables, mediators, moderators, and confounders
    Bauman, AE
    Sallis, JF
    Dzewaltowski, DA
    Owen, N
    [J]. AMERICAN JOURNAL OF PREVENTIVE MEDICINE, 2002, 23 (02) : 5 - 14
  • [9] Risk of dementia in diabetes mellitus: a systematic review
    Biessels, GJ
    Staekenborg, S
    Brunner, E
    Brayne, C
    Scheltens, P
    [J]. LANCET NEUROLOGY, 2006, 5 (01) : 64 - 74
  • [10] Poor Decision Making Is a Consequence of Cognitive Decline among Older Persons without Alzheimer's Disease or Mild Cognitive Impairment
    Boyle, Patricia A.
    Yu, Lei
    Wilson, Robert S.
    Gamble, Keith
    Buchman, Aron S.
    Bennett, David A.
    [J]. PLOS ONE, 2012, 7 (08):