A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity

被引：44

作者：

Wang, Fei ^{[2
,3
]}

Gao, Yuan ^{[3
]}

Zhang, Ling ^{[2
]}

Bai, Bing ^{[2
]}

Hu, Ya Nan ^{[1
]}

Dong, Ze Jun ^{[2
]}

Zhai, Qi Wei ^{[1
]}

Zhu, Hua Jie ^{[2
]}

Liu, Ji Kai ^{[2
]}

机构：

[1] BioBioPha Co Ltd, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 14期

基金：

中国国家自然科学基金;

关键词：

SESQUITERPENE LACTONES; OPTICAL-ROTATION; WATER EXTRACT; STRYCHNIFOLIA; ROOT; BUTANOLIDES;

D O I：

10.1021/ol1011289

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant tinders aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance.

引用

页码：3196 / 3199

页数：4

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