The impact of L1 retrotransposons on the human genome

被引：392

作者：

Kazazian, HH ^{[1
]}

Moran, JV ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

来源：

NATURE GENETICS | 1998年 / 19卷 / 01期

关键词：

D O I：

10.1038/ng0598-19

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The 'master' human mobile element, the L1 retrotransposon, has come of age as a biological entity. Knowledge of how it retrotransposes in vivo, how its proteins act to retrotranspose other poly A elements and the extent of its role in shaping the human genome should emerge rapidly over the next few years. We review the impact of retrotransposons and how new insight is likely to lead to important practical applications for these intriguing mobile elements.

引用

页码：19 / 24

页数：6

共 68 条

[1] ABERRANT TRANSCRIPTION CAUSED BY THE INSERTION OF AN EARLY TRANSPOSABLE ELEMENT IN AN INTRON OF THE FAS ANTIGEN GENE OF LPR MICE [J].

ADACHI, M ;

WATANABEFUKUNAGA, R ;

NAGATA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) :1756-1760

[2]

Argeson AC, 1996, GENETICS, V142, P557

[3] BINDING OF THE UBIQUITOUS NUCLEAR TRANSCRIPTION FACTOR YY1 TO A CIS REGULATORY SEQUENCE IN THE HUMAN LINE-1 TRANSPOSABLE ELEMENT [J].

BECKER, KG ;

SWERGOLD, GD ;

OZATO, K ;

THAYER, RE .

HUMAN MOLECULAR GENETICS, 1993, 2 (10) :1697-1702

[4] LINEs and Alus - The polyA connection [J].

Boeke, JD .

NATURE GENETICS, 1997, 16 (01) :6-7

[5] DEVELOPMENTAL AND CELL-TYPE SPECIFICITY OF LINE-1 EXPRESSION IN MOUSE TESTIS - IMPLICATIONS FOR TRANSPOSITION [J].

BRANCIFORTE, D ;

MARTIN, SL .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (04) :2584-2592

[6]

BRATTHAUER GL, 1992, ONCOGENE, V7, P507

[7]

CHANG DY, 1995, MOL CELL BIOL, V15, P2109

[8]

CHANG DY, 1993, J BIOL CHEM, V268, P6423

[9] A HUMAN ALU RNA-BINDING PROTEIN WHOSE EXPRESSION IS ASSOCIATED WITH ACCUMULATION OF SMALL CYTOPLASMIC ALU RNA [J].

CHANG, DY ;

NELSON, B ;

BILYEU, T ;

HSU, K ;

DARLINGTON, GJ ;

MARAIA, RJ .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (06) :3949-3959

[10] Functional differences between the human LINE retrotransposon and retroviral reverse transcriptases for in vivo mRNA reverse transcription [J].

Dhellin, O ;

Maestre, J ;

Heidmann, T .

EMBO JOURNAL, 1997, 16 (21) :6590-6602

← 1 2 3 4 5 6 7 →