AN ENRICHED ENVIRONMENT MITIGATES THE BRAIN-DISRUPTIVE EFFECTS OF PRENATAL DIETHYLSTILBESTROL EXPOSURE IN MICE

被引:15
作者
Soeda, F. [1 ]
Tanaka, A. [1 ]
Shirasaki, T. [1 ]
Takahama, K. [1 ]
机构
[1] Kumamoto Univ, Dept Environm & Mol Hlth Sci, Grad Sch Pharmaceut Sci, Kumamoto 8620973, Japan
关键词
environmental enrichment; endocrine disrupter; learning and memory; cell proliferation; phosphorylated CaM kinase II; passive avoidance response; PROTEIN-KINASE-II; TS65DN MOUSE MODEL; SYNAPTIC PLASTICITY; RAT HIPPOCAMPUS; DOWN-SYNDROME; DEPENDENT PLASTICITY; HUNTINGTONS-DISEASE; ADULT HIPPOCAMPUS; SPATIAL MEMORY; NEUROGENESIS;
D O I
10.1016/j.neuroscience.2010.04.047
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents. We previously reported that prenatal exposure to diethylstilbestrol (DES) impaired passive avoidance responses and increased levels of phosphorylated Ca2+/calmodulin-dependent protein kinase II (pCaMKII) in the hippocampus of mice. In this study, we examined whether an enriched environment affects the behavioral and neurochemical changes induced in mice prenatally exposed to DES. Male DES-exposed mice were placed in a standard or enriched environment at 3 weeks of age and subjected to behavioral testing after 3 weeks of exposure to these environments. Immunoblot analysis and 5-bromodeoxyuridine (BrdU) immunohistochemistry were then performed. In DES-exposed mice reared in an enriched environment, passive avoidance responses were significantly improved compared to those in mice reared in a standard environment. Moreover, the increase in level of pCaMKII in the hippocampus of DES-exposed mice was reversed by rearing in an enriched environment. Numbers of BrdU-positive cells in the dentate gyrus were significantly increased in normal and DES-exposed mice reared in the enriched environment compared to those in mice reared in the standard environment. These findings suggest that rearing in an enriched environment may mitigate the defects in brain function induced by prenatal exposure to endocrine disrupters such as DES. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:223 / 228
页数:6
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