Sweet clearance:: Involvement of cell surface glycans in the recognition of apoptotic cells

被引：13

作者：

Sarter, Kerstin

Mierke, Claudia

Beer, Alexandra

Frey, Benjamin

Fuehrnrohr, Barbara G.

Schulze, Connie

Franz, Sandra

机构：

[1] Univ Erlangen Nurnberg, Inst Clin Immunol & Rheumatol, Dept Internal Med 3, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Ctr Med Phys & Technol, Biophys Grp, D-91052 Erlangen, Germany

[3] Univ Erlangen Nurnberg, Dept Radiooncol, D-91054 Erlangen, Germany

[4] Univ Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, IZKF Res Grp 2, D-91054 Erlangen, Germany

来源：

AUTOIMMUNITY | 2007年 / 40卷 / 04期

关键词：

apoptosis; carbohydrates; lectins; clearance;

D O I：

10.1080/08916930701356804

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glycans cover the surfaces of all mammalian cells. Their structural variety provides enormous potential for information storage and transfer. According to the concept of the sugar code, they act as biochemical signals decoded by a large number of lectins which are defined as sugar binding proteins. The importance of glycan-lectin interaction in diverse immune system functions becomes increasingly apparent. Here, we review apoptotic cell clearance and especially focus on modifications of glycans on apoptotic cells.

引用

页码：345 / 348

页数：4

共 19 条

[1] Alterations in cell surface phosphatidylserine and sugar chains during apoptosis and their time-dependent role in phagocytosis by macrophages [J].