Of mitochondrion and COVID-19

被引：25

作者：

Alfarouk, Khalid Omer ^{[1
,2
,3
]}

Alhoufie, Sari T. S. ^{[4
]}

Hifny, Abdelhameed ^{[5
]}

Schwartz, Laurent ^{[6
]}

Alqahtani, Ali S. ^{[7
]}

Ahmed, Samrein B. M. ^{[8
]}

Alqahtani, Ali M. ^{[9
]}

Alqahtani, Saad S. ^{[10
]}

Muddathir, Abdel Khalig ^{[11
]}

Ali, Heyam ^{[11
]}

Bashir, Adil H. H. ^{[12
]}

Ibrahim, Muntaser E. ^{[12
]}

Greco, Maria Raffaella ^{[13
]}

Cardone, Rosa A. ^{[13
]}

Harguindey, Salvador ^{[14
]}

Reshkin, Stephan Joel ^{[13
]}

机构：

[1] Zamzam Univ Coll, Res Ctr, Khartoum, Sudan

[2] Hala Alfarouk Canc Ctr, Dept Evolutionary Pharmacol & Tumor Metab, Khartoum 11123, Sudan

[3] Al Ghad Int Coll Appl Med Sci, Al Madinah Al Munwarah, Saudi Arabia

[4] Taibah Univ, Coll Appl Med Sci, Med Labs Technol Dept, Al Madinah Al Munwarah, Saudi Arabia

[5] Al Azhar Univ, Fac Med, Cairo, Egypt

[6] AP HP, Paris, France

[7] Najran Univ, Coll Appl Med Sci, Najran, Saudi Arabia

[8] Univ Sharjah, Coll Med, Sharjah, U Arab Emirates

[9] King Khalid Univ, Coll Pharm, Dept Pharmacol, Abha, Saudi Arabia

[10] Jazan Univ, Coll Pharm, Clin Pharm Dept, Pharm Practice Res Unit, Jazan, Saudi Arabia

[11] Univ Khartoum, Fac Pharm, Khartoum, Sudan

[12] Univ Khartoum, Inst Endem Dis, Khartoum, Sudan

[13] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, Bari, Italy

[14] Inst Clin Biol & Metab, Vitoria, Spain

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2021年 / 36卷 / 01期

关键词：

COVID-19; mitochondrion; inflammation; cytokine storm; treatment; WHEAT-GERM EXTRACT; BOUND IRON UPTAKE; D-DIMER; MYOCARDIAL-INFARCTION; MOLECULAR-MECHANISMS; LACTATE TRANSPORT; CARDIAC TROPONINS; OXIDATIVE STRESS; ACTIVATION; METABOLISM;

D O I：

10.1080/14756366.2021.1937144

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction. Therefore, targeting mitochondrion will represent a more rational treatment of COVID-19. The current work outlines how COVID-19's signs and symptoms are related to the mitochondrion. Proper understanding of the underlying causes might enhance the opportunity to treat COVID-19.

引用

页码：1258 / 1267

页数：9

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