Polymeric Anti-HIV Therapeutics

被引：22

作者：

Danial, Maarten ^{[1
,2
,3
]}

Klok, Harm-Anton ^{[1
,2
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland

[2] Inst Sci & Ingn Chim, Lab Polymeres, CH-1015 Lausanne, Switzerland

[3] CSIRO Mat Sci & Engn, Clayton, Vic 3168, Australia

来源：

MACROMOLECULAR BIOSCIENCE | 2015年 / 15卷 / 01期

关键词：

antiviral; HIV polymer therapeutics; inhibitor; microbicide; polyvalency; HUMAN-IMMUNODEFICIENCY-VIRUS; DEXTRAN SULFATE; DC-SIGN; ANTIRETROVIRAL THERAPY; RADICAL POLYMERIZATION; ENVELOPE GLYCOPROTEIN; IN-VITRO; SYNTHETIC PEPTIDE; CRYSTAL-STRUCTURE; DENDRITIC CELLS;

D O I：

10.1002/mabi.201400298

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretroviral drugs that inhibit critical steps in the HIV infection process is highlighted. After that, a comprehensive overview of the structure and inhibitory properties of polymeric anti-HIV therapeutic agents is presented. This overview will include inhibitors based on polysaccharides, synthetic polymers, dendritic polymers, polymer conjugates as well as polymeric DC-SIGN antagonists. The review will conclude with a section that discusses the applications of polymers and polymer conjugates as systemic and topical anti-HIV therapeutics.

引用

页码：9 / 35

页数：27

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