Energy metabolic pathways control the fate and function of myeloid immune cells

被引：45

作者：

Al-Khami, Amir A. ^{[1
,2
]}

Rodriguez, Paulo C. ^{[4
]}

Ochoa, Augusto C. ^{[1
,3
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Stanley S Scott Canc Ctr, 1700 Tulane Ave,906, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Dept Genet, 1700 Tulane Ave,906, New Orleans, LA 70112 USA

[3] Louisiana State Univ, Hlth Sci Ctr, Dept Pediat, 1700 Tulane Ave,910, New Orleans, LA 70112 USA

[4] Augusta Univ, Georgia Canc Ctr, Augusta, GA USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2017年 / 102卷 / 02期

基金：

美国国家卫生研究院;

关键词：

neutrophil; macrophage; dendritic cell; MDSC; NEUTROPHIL EXTRACELLULAR TRAPS; TRANSCRIPTION FACTOR ACTIVITY; SUPPRESSOR-CELLS; DENDRITIC CELL; T-CELLS; NITRIC-OXIDE; MACROPHAGE POLARIZATION; TUMOR MICROENVIRONMENT; IMMUNOSUPPRESSIVE ACTIVITY; ALTERNATIVE ACTIVATION;

D O I：

10.1189/jlb.1VMR1216-535R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past decade has seen a significant interest in investigating the intracellular metabolism of cells of the immune system. This has increased the realization that immune cells endure metabolic reprogramming upon responding to pathogen-derived or inflammatory signals. More importantly, not only does this metabolic switch provide for the bioenergetic and biosynthetic demands but also it, in a highly specific manner, determines the cellular fate and function. In this review, we discuss the metabolic aspects that regulate the differentiation and function of myeloid cells, pivotal for both innate and adaptive immunity. The manipulation of these pathways can alter the function of these cells and therefore, could provide novel therapeutic approaches in cancer and other chronic inflammatory conditions.

引用

页码：369 / 380

页数：12

共 158 条

[1] Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer [J].

Al-Khami, Amir A. ;

Rodriguez, Paulo C. ;

Ochoa, Augusto C. .

ONCOIMMUNOLOGY, 2016, 5 (08)

[2] Inhibition of Mechanistic Target of Rapamycin Promotes Dendritic Cell Activation and Enhances Therapeutic Autologous Vaccination in Mice [J].

Amiel, Eyal ;

Everts, Bart ;

Freitas, Tori C. ;

King, Irah L. ;

Curtis, Jonathan D. ;

Pearce, Erika L. ;

Pearce, Edward J. .

JOURNAL OF IMMUNOLOGY, 2012, 189 (05) :2151-2158

[3] Proteomic characterization of human proinflammatory M1 and anti-inflammatory M2 macrophages and their response to Candida albicans [J].

Antonio Reales-Calderon, Jose ;

Aguilera-Montilla, Noemi ;

Luis Corbi, Angel ;

Molero, Gloria ;

Gil, Concha .

PROTEOMICS, 2014, 14 (12) :1503-1518

[4] The effect of nitric oxide on cell respiration:: A key to understanding its role in cell survival or death [J].

Beltrán, B ;

Mathur, A ;

Duchen, MR ;

Erusalimsky, JD ;

Moncada, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) :14602-14607

[5] Macrophage polarization in bacterial infections [J].

Benoit, Marie ;

Desnues, Benoit ;

Mege, Jean-Louis .

JOURNAL OF IMMUNOLOGY, 2008, 181 (06) :3733-3739

[6] Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions [J].

Boor, P. P. C. ;

Metselaar, H. J. ;

Mancham, S. ;

van der Laan, L. J. W. ;

Kwekkeboom, J. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2013, 174 (03) :389-401

[7] ENERGY-METABOLISM OF HUMAN-NEUTROPHILS DURING PHAGOCYTOSIS [J].

BORREGAARD, N ;

HERLIN, T .

JOURNAL OF CLINICAL INVESTIGATION, 1982, 70 (03) :550-557

[8]

Brito C, 1999, J IMMUNOL, V162, P3356

[9] IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice [J].

Bronte, V ;

Serafini, P ;

De Santo, C ;

Marigo, I ;

Tosello, V ;

Mazzoni, A ;

Segal, DM ;

Staib, C ;

Lowel, M ;

Sutter, G ;

Colombo, MP ;

Zanovello, P .

JOURNAL OF IMMUNOLOGY, 2003, 170 (01) :270-278

[10]

Bronte Vincenzo, 2000, Blood, V96, P3838

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