Genetic association of complement component 2 variants with chronic hepatitis B in a Korean population

被引:5
作者
Namgoong, Suhg [1 ]
Shin, Joong-Gon [2 ]
Cheong, Hyun Sub [3 ]
Kim, Lyoung Hyo [3 ]
Kim, Ji On [3 ]
Seo, Jung Yeon [1 ]
Shin, Hyoung Doo [1 ,2 ]
Kim, Yoon Jun [4 ,5 ]
机构
[1] Sogang Univ, Dept Life Sci, Seoul, South Korea
[2] Sogang Univ, Res Inst Basic Sci, Seoul, South Korea
[3] SNP Genet Inc, Dept Genet Epidemiol, Seoul, South Korea
[4] Seoul Natl Univ, Dept Internal Med, Seoul, South Korea
[5] Seoul Natl Univ, Liver Res Inst, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
chronic hepatitis B; complement component 2; genetic risk score; single nucleotide polymorphism; GENOME-WIDE ASSOCIATION; MACULAR DEGENERATION; RISK-FACTORS; POLYMORPHISMS; HLA; TYPE-1; LOCUS;
D O I
10.1111/liv.13675
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Numerous single nucleotide polymorphisms associated with an increased risk of liver diseases, chronic hepatitis B and chronic hepatitis B-related hepatocellular carcinoma have been identified. In this study, we scrutinized the genetic effects of C2 variants, which were conflicting in previous results, on the risk of chronic hepatitis B in a Korean population. Methods: We genotyped 22 common C2 genetic variants of 977 chronic hepatitis B cases including 302 chronic hepatitis B-related hepatocellular carcinoma cases and 785 population controls. Statistical analysis was performed to examine the effects of genotype on the risk of chronic hepatitis B and chronic hepatitis B-related hepatocellular carcinoma. Results: Logistic regression analyses showed that six C2 single nucleotide polymorphisms had significant associations with the risk of chronic hepatitis B and chronic hepatitis B-related hepatocellular carcinoma among the Korean subjects. Step-wise analysis revealed that causal markers (rs9267665 and rs10947223) were identified among the C2 variants (stepwise P = 3.32 x 10(-9) and 2.04 x 10(-5) respectively). In further conditional analysis with previous chronic hepatitis B-associated loci, these two single nucleotide polymorphisms were independently associated with the risk of chronic hepatitis B. In addition, we investigated the ability of genetic risk scores combining 12 multi-chronic hepatitis B loci to predict the risk of chronic hepatitis B. Individuals with higher genetic risk scores showed increased risk for chronic hepatitis B. Conclusions: Our results suggested that the C2 gene might be a susceptibility locus for chronic hepatitis B in Korean populations. The cumulative genetic effects may contribute to future etiological explanations for chronic hepatitis B.
引用
收藏
页码:1576 / 1582
页数:7
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