Synthesis, characterization, antibacterial and antiproliferative activities of monodisperse chitosan- based silver nanoparticles

被引：139

作者：

Hoang Vinh Tran ^{[2
]}

Lam Dai Tran ^{[1
]}

Cham Thi Ba ^{[3
]}

Hoang Dinh Vu ^{[2
]}

Thinh Ngoc Nguyen ^{[2
]}

Dien Gia Pham ^{[3
]}

Phuc Xuan Nguyen ^{[1
]}

机构：

[1] Vietnamese Acad Sci & Technol, Inst Mat Sci, Hanoi, Vietnam

[2] Hanoi Univ Technol, Fac Chem Technol, Hanoi, Vietnam

[3] Vietnamese Acad Sci & Technol, Inst Chem, Hanoi, Vietnam

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2010年 / 360卷 / 1-3期

关键词：

Silver nanoparticles (AgNPs); Chitosan (CS); Kinetics; Antibacterial and antiproliferative activities; REDUCTION; METAL; GOLD; AG+;

D O I：

10.1016/j.colsurfa.2010.02.007

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Silver nanoparticles (AgNPs) have been known to have inhibitory and bactericidal effects In this paper we investigated. (i) the synthesis and kinetics of finely dispersed AgNPs in a biocompatible chitosan-derived polysaccharide solution, (ii) the antibacterial activities toward both gram (Escherichia colt and Pseudomonas aeruginosa) and gram(+) bacteria (Lactobacillus fermentum. Staphylococcus aureus and Bacillus subtilis) and yeast (Candida albicans) of the obtained AgNPs, and (in) in vitro cytotoxicity against HepG2 (hepatocellular carcinoma), Lu (human lung carcinoma), KB (human epidermic carcinoma), MCF-7 (human breast carcinoma) cancer cell lines. The samples demonstrated considerably high antibacterial and antiproliferative activities against above bacterial strains and cell lines, which can be explained on the basis of finely and homogenously dispersed nanoparticles. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：32 / 40

页数：9

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