Effectiveness of COVID-19 vaccines in preventing SARS-CoV-2 infection and hospitalisation, Navarre, Spain, January to April 2021

被引：64
作者：
Martinez-Baz, Ivan [1 ,2 ,3 ]
Miqueleiz, Ana [3 ,4 ]
Casado, Itziar [1 ,2 ,3 ]
Navascues, Ana [3 ,4 ]
Trobajo-Sanmartin, Camino [3 ,4 ]
Burgui, Cristina [1 ,2 ,3 ]
Guevara, Marcela [1 ,2 ,3 ]
Ezpeleta, Carmen [3 ,4 ]
Castilla, Jesus [1 ,2 ,3 ]
机构：
[1] Inst Salud Publ Navarra, Pamplona, Spain
[2] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
[3] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain
[4] Complejo Hosp Navarra, Dept Clin Microbiol, Pamplona, Spain
来源：
EUROSURVEILLANCE | 2021年 / 26卷 / 21期
基金：
欧盟地平线“2020”;
关键词：
D O I：
10.2807/1560-7917.ES.2021.26.21.2100438
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
COVID-19 vaccine effectiveness was evaluated in close contacts of cases diagnosed during January-April 2021. Among 20,961 contacts, 7,240 SARS-CoV-2 infections were confirmed, with 5,467 being symptomatic and 559 leading to hospitalisations. Non-brand-specific one and two dose vaccine effectiveness were respectively, 35% (95% confidence interval (CI): 25 to 44) and 66% (95% CI: 57 to 74) against infections, 42% (95% CI: 31 to 52) and 82% (95% CI: 74 to 88) against symptomatic infection, and 72% (95% CI: 47 to 85) and 95% (95% CI: 62 to 99) against COVID-19 hospitalisation. The second dose significantly increased effectiveness. Findings support continuing complete vaccination.
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共 20 条
  • [11] Theoretical Framework for Retrospective Studies of the Effectiveness of SARS-CoV-2 Vaccines
    Lewnard, Joseph A.
    Patel, Manish M.
    Jewell, Nicholas P.
    Verani, Jennifer R.
    Kobayashi, Miwako
    Tenforde, Mark W.
    Dean, Natalie E.
    Cowling, Benjamin J.
    Lopman, Benjamin A.
    [J]. EPIDEMIOLOGY, 2021, 32 (04) : 508 - 517
  • [12] Ministerio de Sanidad, ESTR DET PREC VIG CO
  • [13] Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
    Polack, Fernando P.
    Thomas, Stephen J.
    Kitchin, Nicholas
    Absalon, Judith
    Gurtman, Alejandra
    Lockhart, Stephen
    Perez, John L.
    Perez Marc, Gonzalo
    Moreira, Edson D.
    Zerbini, Cristiano
    Bailey, Ruth
    Swanson, Kena A.
    Roychoudhury, Satrajit
    Koury, Kenneth
    Li, Ping
    Kalina, Warren V.
    Cooper, David
    Frenck, Robert W., Jr.
    Hammitt, Laura L.
    Tureci, Ozlem
    Nell, Haylene
    Schaefer, Axel
    Unal, Serhat
    Tresnan, Dina B.
    Mather, Susan
    Dormitzer, Philip R.
    Sahin, Ugur
    Jansen, Kathrin U.
    Gruber, William C.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) : 2603 - 2615
  • [14] Swift MD., 2021, CLIN INFECT DIS, V73, pe1376, DOI DOI 10.1093/CID/CIAB361
  • [15] Tenforde MW, 2021, MMWR-MORBID MORTAL W, V70, P674, DOI 10.15585/mmwr.mm7018e1
  • [16] Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers - Eight US Locations, December 2020-March 2021
    Thompson, Mark G.
    Burgess, Jefferey L.
    Naleway, Allison L.
    Tyner, Harmony L.
    Yoon, Sarang K.
    Meece, Jennifer
    Olsho, Lauren E. W.
    Caban-Martinez, Alberto J.
    Fowlkes, Ashley
    Lutrick, Karen
    Kuntz, Jennifer L.
    Dunnigan, Kayan
    Odean, Marilyn J.
    Hegmann, Kurt T.
    Stefanski, Elisha
    Edwards, Laura J.
    Schaefer-Solle, Natasha
    Grant, Lauren
    Ellingson, Katherine
    Groom, Holly C.
    Zunie, Tnelda
    Thiese, Matthew S.
    Ivacic, Lynn
    Wesley, Meredith G.
    Lamberte, Julie Mayo
    Sun, Xiaoxiao
    Smith, Michael E.
    Phillips, Andrew L.
    Groover, Kimberly D.
    Yoo, Young M.
    Gerald, Joe
    Brown, Rachel T.
    Herring, Meghan K.
    Joseph, Gregory
    Beitel, Shawn
    Morrill, Tyler C.
    Mak, Josephine
    Rivers, Patrick
    Harris, Katherine M.
    Hunt, Danielle R.
    Arvay, Melissa L.
    Kutty, Preeta
    Fry, Alicia M.
    Gaglani, Manjusha
    [J]. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2021, 70 (13): : 495 - 500
  • [17] Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study
    Vasileiou, Eleftheria
    Simpson, Colin R.
    Shi, Ting
    Kerr, Steven
    Agrawal, Utkarsh
    Akbari, Ashley
    Bedston, Stuart
    Beggs, Jillian
    Bradley, Declan
    Chuter, Antony
    de Lusignan, Simon
    Docherty, Annemarie B.
    Ford, David
    Hobbs, F. D. Richard
    Joy, Mark
    Katikireddi, Srinivasa Vittal
    Marple, James
    McCowan, Colin
    McGagh, Dylan
    McMenamin, Jim
    Moore, Emily
    Murray, Josephine L. K.
    Pan, Jiafeng
    Ritchie, Lewis
    Shah, Syed Ahmar
    Stock, Sarah
    Torabi, Fatemeh
    Tsang, Ruby S. M.
    Wood, Rachael
    Woolhouse, Mark
    Robertson, Chris
    Sheikh, Aziz
    [J]. LANCET, 2021, 397 (10285) : 1646 - 1657
  • [18] Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials
    Voysey, Merryn
    Clemens, Sue Ann Costa
    Madhi, Shabir A.
    Weckx, Lily Y.
    Folegatti, Pedro M.
    Aley, Parvinder K.
    Angus, Brian
    Baillie, Vicky L.
    Barnabas, Shaun L.
    Bhorat, Qasim E.
    Bibi, Sagida
    Briner, Carmen
    Cicconi, Paola
    Clutterbuck, Elizabeth A.
    Collins, Andrea M.
    Cutland, Clare L.
    Darton, Thomas C.
    Dheda, Keertan
    Dold, Christina
    Duncan, Christopher J. A.
    Emary, Katherine R. W.
    Ewer, Katie J.
    Flaxman, Amy
    Fairlie, Lee
    Faust, Saul N.
    Feng, Shuo
    Ferreira, Daniela M.
    Finn, Adam
    Galiza, Eva
    Goodman, Anna L.
    Green, Catherine M.
    Green, Christopher A.
    Greenland, Melanie
    Hill, Catherine
    Hill, Helen C.
    Hirsch, Ian
    Izu, Alane
    Jenkin, Daniel
    Joe, Carina C. D.
    Kerridge, Simon
    Koen, Anthonet
    Kwatra, Gaurav
    Lazarus, Rajeka
    Libri, Vincenzo
    Lillie, Patrick J.
    Marchevsky, Natalie G.
    Marshall, Richard P.
    Mendes, Ana V. A.
    Milan, Eveline P.
    Minassian, Angela M.
    [J]. LANCET, 2021, 397 (10277) : 881 - 891
  • [19] WHO, 2021, EV COVID 19 VACC EFF
  • [20] World Health Organization (WHO), WHO COR COVID 19 DAS
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