Effectiveness of COVID-19 vaccines in preventing SARS-CoV-2 infection and hospitalisation, Navarre, Spain, January to April 2021

被引：64
作者：
Martinez-Baz, Ivan [1 ,2 ,3 ]
Miqueleiz, Ana [3 ,4 ]
Casado, Itziar [1 ,2 ,3 ]
Navascues, Ana [3 ,4 ]
Trobajo-Sanmartin, Camino [3 ,4 ]
Burgui, Cristina [1 ,2 ,3 ]
Guevara, Marcela [1 ,2 ,3 ]
Ezpeleta, Carmen [3 ,4 ]
Castilla, Jesus [1 ,2 ,3 ]
机构：
[1] Inst Salud Publ Navarra, Pamplona, Spain
[2] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
[3] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain
[4] Complejo Hosp Navarra, Dept Clin Microbiol, Pamplona, Spain
来源：
EUROSURVEILLANCE | 2021年 / 26卷 / 21期
基金：
欧盟地平线“2020”;
关键词：
D O I：
10.2807/1560-7917.ES.2021.26.21.2100438
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
COVID-19 vaccine effectiveness was evaluated in close contacts of cases diagnosed during January-April 2021. Among 20,961 contacts, 7,240 SARS-CoV-2 infections were confirmed, with 5,467 being symptomatic and 559 leading to hospitalisations. Non-brand-specific one and two dose vaccine effectiveness were respectively, 35% (95% confidence interval (CI): 25 to 44) and 66% (95% CI: 57 to 74) against infections, 42% (95% CI: 31 to 52) and 82% (95% CI: 74 to 88) against symptomatic infection, and 72% (95% CI: 47 to 85) and 95% (95% CI: 62 to 99) against COVID-19 hospitalisation. The second dose significantly increased effectiveness. Findings support continuing complete vaccination.
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  • [1] Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centres
    Albert, Eliseo
    Torres, Ignacio
    Bueno, Felipe
    Huntley, Dixie
    Molla, Estefania
    Angel Fernandez-Fuentes, Miguel
    Martinez, Mireia
    Poujois, Sandrine
    Forque, Lorena
    Valdivia, Arantxa
    Solano de la Asuncion, Carlos
    Ferrer, Josep
    Colomina, Javier
    Navarro, David
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2021, 27 (03) : 472.e7 - 472.e10
  • [2] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
    Baden, Lindsey R.
    El Sahly, Hana M.
    Essink, Brandon
    Kotloff, Karen
    Frey, Sharon
    Novak, Rick
    Diemert, David
    Spector, Stephen A.
    Rouphael, Nadine
    Creech, C. Buddy
    McGettigan, John
    Khetan, Shishir
    Segall, Nathan
    Solis, Joel
    Brosz, Adam
    Fierro, Carlos
    Schwartz, Howard
    Neuzil, Kathleen
    Corey, Larry
    Gilbert, Peter
    Janes, Holly
    Follmann, Dean
    Marovich, Mary
    Mascola, John
    Polakowski, Laura
    Ledgerwood, Julie
    Graham, Barney S.
    Bennett, Hamilton
    Pajon, Rolando
    Knightly, Conor
    Leav, Brett
    Deng, Weiping
    Zhou, Honghong
    Han, Shu
    Ivarsson, Melanie
    Miller, Jacqueline
    Zaks, Tal
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) : 403 - 416
  • [3] Consejo interterritorial Sistema Nacional de Salud Ministerio de Sanidad Consumo y Bienestar Social, 2021, ESTR VAC FRENT COVID
  • [4] BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting
    Dagan, Noa
    Barda, Noam
    Kepten, Eldad
    Miron, Oren
    Perchik, Shay
    Katz, Mark A.
    Hernan, Miguel A.
    Lipsitch, Marc
    Reis, Ben
    Balicer, Ran D.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (15) : 1412 - 1423
  • [5] Methods for estimating relative risk in studies of common binary outcomes
    Dwivedi, Alok Kumar
    Mallawaarachchi, Indika
    Lee, Soyoung
    Tarwater, Patrick
    [J]. JOURNAL OF APPLIED STATISTICS, 2014, 41 (03) : 484 - 500
  • [6] Ecdc, 2020, CONT TRAC PUBL HLTH
  • [7] European Center for Disease Prevention and Control (ECDC), 2020, Options for the Use of Rapid Antigen Tests for COVID-19 in the EU/EEA and the UK
  • [8] European Centre for Disease Prevention and Control (ECDC), CAS DEF COR DIS 2019
  • [9] Effectiveness of the Comirnaty (BNT162b2, BioNTech/Pfizer) vaccine in preventing SARS-CoV-2 infection among healthcare workers, Treviso province, Veneto region, Italy, 27 December 2020 to 24 March 2021
    Fabiani, Massimo
    Ramigni, Mauro
    Gobbetto, Valentina
    Mateo-Urdiales, Alberto
    Pezzotti, Patrizio
    Piovesan, Cinzia
    [J]. EUROSURVEILLANCE, 2021, 26 (17) : 1 - 7
  • [10] Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data
    Haas, Eric J.
    Angulo, Frederick J.
    McLaughlin, John M.
    Anis, Emilia
    Singer, Shepherd R.
    Khan, Farid
    Brooks, Nati
    Smaja, Meir
    Mircus, Gabriel
    Pan, Kaijie
    Southern, Jo
    Swerdlow, David L.
    Jodar, Luis
    Levy, Yeheskel
    Alroy-Preis, Sharon
    [J]. LANCET, 2021, 397 (10287) : 1819 - 1829
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