Lack of involvement of alpha-synuclein in unconditioned anxiety in mice

被引：27
|
作者：
Pena-Oliver, Yolanda [1 ]
Buchman, Vladimir L. [2 ]
Stephens, David N. [1 ]
机构：
[1] Univ Sussex, Dept Psychol, Brighton BN1 9QG, E Sussex, England
[2] Cardiff Univ, Sch Biosci, Cardiff CF10 3AX, S Glam, Wales
来源：
BEHAVIOURAL BRAIN RESEARCH | 2010年 / 209卷 / 02期
基金：
英国惠康基金;
关键词：
Alpha-synuclein; Anxiety; Mice; Open field; Elevated plus maze; Light-dark box; ELEVATED PLUS-MAZE; PARKINSONS-DISEASE; GAMMA-SYNUCLEIN; DOPAMINERGIC-NEURONS; BEHAVIOR; EXPRESSION; MUTATION; PROTEIN; LOCUS; BRAIN;
D O I：
10.1016/j.bbr.2010.01.049
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Alpha-synuclein is implicated in the pathology of Parkinson disease (PD) and is involved in synaptic function, particularly in presynaptic events in dopamine (DA) synapses. Recently, a role for alpha-synuclein in reward and addiction, especially in alcoholism, has been reported. Since PD and alcohol dependence present a strong comorbidity with anxiety disorders, a role for alpha-synuclein in anxiety has been proposed. The aim of the present investigation was to study the involvement of alpha-synuclein in anxiety by testing alpha-synuclein knock out and wild type mice in three different emotionality tests: the open field, the elevated plus maze and the light-dark box. Alpha-synuclein knock out mice and wild type controls displayed consistently similar emotionality profiles in all the tests, suggesting a lack of involvement of alpha-synuclein in unconditioned anxiety in mice. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：234 / 240
页数：7
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