Neutrophils promote mononuclear cell infiltration during viral-induced encephalitis

被引：122

作者：

Zhou, JH

Stohlman, SA

Hinton, DR

Marten, NW

机构：

[1] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA

[2] Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA

[3] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

来源：

JOURNAL OF IMMUNOLOGY | 2003年 / 170卷 / 06期

关键词：

D O I：

10.4049/jimmunol.170.6.3331

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils are the first infiltrating cell population to appear within the CNS during infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV). To determine whether neutrophils play a role in limiting acute JHMV infection, mice were depleted of neutrophils. Infection of neutropenic animals resulted in increased levels of virus replication and mortality compared with control mice. Furthermore, neutropenia resulted in significantly reduced mononuclear leukocyte infiltration possibly due to reduced loss of blood brain barrier integrity during acute JHMV infection. These data suggest that infiltrating neutrophils are crucial for limiting virus replication during acute JHMV infection, contribute to the loss of blood brain barrier integrity and play a role in shaping adaptive immunity within the CNS.

引用

页码：3331 / 3336

页数：6

共 42 条

[1] The severity of Murray Valley encephalitis in mice is linked to neutrophil infiltration and inducible nitric oxide synthase activity in the central nervous system [J].