A class of improved hybrid Hochberg-Hommel type step-up multiple test procedures

被引:32
作者
Gou, Jiangtao [1 ]
Tamhane, Ajit C. [2 ]
Xi, Dong [3 ]
Rom, Dror [4 ]
机构
[1] Northwestern Univ, Dept Stat, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Ind Engn & Management Sci, Evanston, IL 60208 USA
[3] Novartis Pharmaceut, Stat Methodol, E Hanover, NJ 07936 USA
[4] Prosoft Inc, Wayne, PA 19087 USA
关键词
Adjusted p-value; Closure method; Consonant procedure; Familywise error rate; p-value based multiple test procedure; Stepwise procedure; BONFERRONI PROCEDURE;
D O I
10.1093/biomet/asu032
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this paper we derive a new p-value based multiple testing procedure that improves upon the Hommel procedure by gaining power as well as having a simpler step-up structure similar to the Hochberg procedure. The key to this improvement is that the Hommel procedure can be improved by a consonant procedure. Exact critical constants of this new procedure can be numerically determined. The zeroth-order approximations to the exact critical constants, albeit slightly conservative, are simple to use and need no tabling, and hence are recommended in practice. The proposed procedure is shown to control the familywise error rate under independence among the p-values. Simulations empirically demonstrate familywise error rate control under positive and negative dependence. Power superiority of the proposed procedure over competing ones is also empirically demonstrated. Illustrative examples are given.
引用
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页码:899 / 911
页数:13
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