Sperm DNA damage in male infertility: etiologies, assays, and outcomes

被引：197

作者：

Schulte, Ryan T. ^{[1
]}

Ohl, Dana A. ^{[1
]}

Sigman, Mark ^{[2
]}

Smith, Gary D. ^{[1
,3
,4
,5
]}

机构：

[1] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[2] Brown Med Sch, Dept Urol, Providence, RI 02912 USA

[3] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Integrated & Mol Physiol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Reprod Sci Program, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2010年 / 27卷 / 01期

关键词：

Etiologies; Assays; Sperm; DNA Damage; CHROMATIN-STRUCTURE ASSAY; IN-VITRO FERTILIZATION; DEOXYRIBONUCLEIC-ACID FRAGMENTATION; BECKWITH-WIEDEMANN-SYNDROME; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE; STRAND BREAKS; HUMAN-SPERMATOZOA; OXIDATIVE STRESS; ASSISTED REPRODUCTION; MAMMALIAN SPERMATOGENESIS;

D O I：

10.1007/s10815-009-9359-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Male factor infertility is the sole cause of infertility in approximately 20% of infertile couples, with an additional 30% to 40% secondary to both male and female factors. Current means of evaluation of male factor infertility remains routine semen analysis including seminal volume, pH, sperm concentration, motility, and morphology. However, approximately 15% of patients with male factor infertility have a normal semen analysis and a definitive diagnosis of male infertility often cannot be made as a result of routine semen analysis. Attention has focused on the role of sperm nuclear DNA integrity in male factor infertility. Here we review the structure of human sperm chromatin, the etiology and mechanisms of sperm DNA damage, current tests available to assess sperm DNA integrity, and effect of sperm DNA integrity on reproductive outcomes.

引用

页码：3 / 12

页数：10

共 133 条

[1] Sperm DNA damage assessment: a test whose time has come [J].