ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate

被引：3
|
作者：
Archer, Leanne K. [1 ]
Frame, Fiona M. [1 ]
Walker, Hannah F. [1 ]
Droop, Alastair P. [3 ]
McDonald, Georgina L. K. [1 ]
Kucko, Samuel [1 ]
Berney, Daniel M. [2 ]
Mann, Vincent M. [1 ]
Simms, Matthew S. [4 ]
Maitland, Norman J. [1 ]
机构：
[1] Univ York, Dept Biol, Canc Res Unit, Heslington YO10 5DD, England
[2] Queen Mary Univ London, Barts Canc Inst, Dept Mol Oncol, London, England
[3] Wellcome Sanger Inst, Expt Canc Genet, Hinxton, England
[4] Castle Hill Hosp, Dept Urol, Cottingham, England
来源：
FEBS OPEN BIO | 2022年 / 12卷 / 07期
关键词：
cell cycle; ELF3; patient samples; prostate; prostate cancer; siRNA; NEUROENDOCRINE DIFFERENTIATION; STEM-CELLS; FUSION GENE; CANCER; EXPRESSION; EVOLUTION; TUMORS; OVEREXPRESSION; LIMITATIONS; CARCINOMA;
D O I：
10.1002/2211-5463.13417
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study aimed to elucidate the role of ELF3, an ETS family member in normal prostate growth and prostate cancer. Silencing ELF3 in both benign prostate (BPH-1) and prostate cancer (PC3) cell lines resulted in decreased colony-forming ability, inhibition of cell migration and reduced cell viability due to cell cycle arrest, establishing ELF3 as a cell cycle regulator. Increased ELF3 expression in more advanced prostate tumours was shown by immunostaining of tissue microarrays and from analysis of gene expression and genetic alteration studies. This study indicates that ELF3 functions not only as a part of normal prostate epithelial growth but also as a potential oncogene in advanced prostate cancers.
引用
收藏
页码：1365 / 1387
页数：23
相关论文
共 50 条
  • [21] Epithelium-Specific Ets-Like Transcription Factor 1, ESE-1, Regulates ICAM-1 Expression in Cultured Lung Epithelial Cell Lines
    Yu, Zhiqi
    Xu, Jun
    Liu, Jinbao
    Wu, Jing
    Lee, Chan Mi
    Yu, Li
    Hu, Jim
    MEDIATORS OF INFLAMMATION, 2015, 2015
  • [22] Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer
    Cangemi, R.
    Mensah, A.
    Albertini, V.
    Jain, A.
    Mello-Grand, M.
    Chiorino, G.
    Catapano, C. V.
    Carbone, G. M.
    ONCOGENE, 2008, 27 (20) : 2877 - 2885
  • [23] Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer
    R Cangemi
    A Mensah
    V Albertini
    A Jain
    M Mello-Grand
    G Chiorino
    C V Catapano
    G M Carbone
    Oncogene, 2008, 27 : 2877 - 2885
  • [24] A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-β type II receptor
    Choi, SG
    Yi, Y
    Kim, YS
    Kato, M
    Chang, J
    Chung, HW
    Hahm, KB
    Yang, HK
    Rhee, HH
    Bang, YJ
    Kim, SJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (01) : 110 - 117
  • [25] The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism
    Prescott, JD
    Koto, KSN
    Singh, M
    Gutierrez-Hartmann, A
    MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (12) : 5548 - 5564
  • [26] Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-β type II receptor expression and restores the TGF-β signaling pathway in Hs578t human breast cancer cells
    Chang, J
    Lee, C
    Hahm, KB
    Yi, Y
    Choi, SG
    Kim, SJ
    ONCOGENE, 2000, 19 (01) : 151 - 154
  • [27] Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-β type II receptor expression and restores the TGF-β signaling pathway in Hs578t human breast cancer cells
    Jay Chang
    Cecile Lee
    Ki-Baik Hahm
    Youngsuk Yi
    Shin-Geon Choi
    Seong-Jin Kim
    Oncogene, 2000, 19 : 151 - 154
  • [28] Activation of the murine type II transforming growth factor-β receptor gene -: Up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1
    Kim, JH
    Wilder, PJ
    Hou, JW
    Nowling, T
    Rizzino, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (20) : 17520 - 17530
  • [29] ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3α gene expression in Caco-2 human colonic epithelial cells
    Kwon, JH
    Keates, S
    Simeonidis, S
    Grall, F
    Libermann, TA
    Keates, AC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (02) : 875 - 884
  • [30] Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3
    Kohno, Yoshiki
    Okamoto, Takeshi
    Ishibe, Tatsuya
    Nagayama, Satoshi
    Shima, Yasuko
    Nishijo, Kohichi
    Shibata, Kotaro R.
    Fukiage, Kenichi
    Otsuka, Seiji
    Uejima, Daisuke
    Araki, Nobuhito
    Naka, Norifumi
    Nakashima, Yasuaki
    Aoyama, Tomoki
    Nakayama, Tomitaka
    Nakamura, Takashi
    Toguchida, Junya
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (50) : 38941 - 38950
12345