Hemodynamic effects of carvedilol infusion and the contribution of the sympathetic nervous system in rats with heart failure

被引:0
|
作者
Abe, Y
Watanabe, K
Sato, S
Nagai, Y
Kamal, FA
Wahed, MII
Wen, J
Narasimman, G
Ma, ML
Suresh, P
Takahashi, T
Tachikawa, H
Kashimura, T
Tanabe, N
Kodama, M
Aizawa, Y
Yamaguchi, K
Miyazaki, M
Kakemi, M
机构
[1] Niigata Univ Pharm & Appl Life Sci, Dept Clin Pharmacol, Niigata 9502081, Japan
[2] Niigata Univ Pharm & Appl Life Sci, Dept Funct Food & Analytic Food Sci, Niigata 9502081, Japan
[3] Niigata Univ, Sch Med & Dent Sci, Radioisotope Ctr, Niigata, Japan
[4] Niigata Univ, Sch Med & Dent Sci, Dept Med 1, Niigata, Japan
[5] Niigata Univ, Sch Med & Dent Sci, Dept Homeostat Regulat & Dev, Niigata, Japan
[6] Osaka Univ Pharmaceut Sci, Dept Pharmaceut, Osaka 580, Japan
关键词
carvedilol; sympathetic nervous system; norepinephrine; chronic heart failure;
D O I
10.1159/000080375
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We investigated the contribution of the sympathetic nervous system ( SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure ( group F). Left ventricular end- diastolic pressure, percent functional shortening, and rates of intraventricular pressure rise were significantly changed by carvedilol infusion as compared with the basal values in group N ( normal rats), but not in group F. The left ventricular end- diastolic pressure was elevated, corresponding to the enhancement of the plasma norepinephrine ( NE) concentration caused by carvedilol infusion, in group N. The enhancement of the plasma NE concentration induced by carvedilol administration in group F was higher than that in group N. The value for the maximal hypertensive effect of NE intravenous infusion ( E (max)) was decreased, and the plasma NE concentration at half- maximal effect ( EC50) was increased in group F as compared with the values in group N. These results indicate that the SNS ( presynaptic) activity is increased and that the SNS receptor sensitivity in the cardiovascular regulation system is decreased in heart failure. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:213 / 219
页数:7
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