Fertilization: a sperm's journey to and interaction with the oocyte

被引：222

作者：

Ikawa, Masahito ^{[1
]}

Inoue, Naokazu ^{[1
]}

Benham, Adam M. ^{[1
,2
]}

Okabe, Masaru ^{[1
]}

机构：

[1] Osaka Univ, Microbial Dis Res Inst, Osaka 5650871, Japan

[2] Univ Durham, Sch Biol & Biomed Sci, Durham DH1 3HP, England

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 04期

基金：

日本学术振兴会;

关键词：

EGG ZONA-PELLUCIDA; GROWTH-DIFFERENTIATION FACTOR-9; ANGIOTENSIN-CONVERTING ENZYME; O-LINKED OLIGOSACCHARIDES; MOUSE GAMETE INTERACTIONS; ACROSOME REACTION; CUMULUS CELLS; MICE LACKING; PLASMA-MEMBRANE; MALE-FERTILITY;

D O I：

10.1172/JCI41585

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mammalian fertilization comprises sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. Recent gene knockout approaches in mice have revealed that many factors previously considered important for fertilization are largely dispensable, or if they are essential, they have an unexpected function. These results indicate that what has been observed in in vitro fertilization (IVF) differs significantly from what occurs during "physiological" fertilization. This Review focuses on the advantages of studying fertilization using gene-manipulated animals and highlights an emerging molecular mechanism of mammalian fertilization.

引用

页码：984 / 994

页数：11

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